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000278927 037__ $$aDZNE-2025-00653
000278927 041__ $$aEnglish
000278927 1001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b0$$eFirst author$$udzne
000278927 245__ $$aAdvances in imaging
000278927 260__ $$bElsevier$$c2025
000278927 29510 $$aEarly Detection in Alzheimer' s Disease / Düzel, Emrah ; : Elsevier, 2025, ; ISBN: 9780128222409 ; doi:10.1016/B978-0-12-822240-9.00015-6
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000278927 520__ $$aAdvances in magnetic resonance imaging (MRI) technology have profoundly transformed our ability to accurately measure brain structures and conduct long-term monitoring of their changes, elucidating the intricate interplay between brain structure, cognition, and health status in response to aging and neurodegeneration. To date, it is clear that volumetric MRI measurements explain a significant portion of the heterogeneity in individuals' cognitive performance and reflect the impact of pathology on the brain. However, recent findings from disease-modifying treatments (DMTs) have demonstrated that slowing cognitive decline does not equate to slowing of brain atrophy. This indicates that we need other measures than atrophy over time to uncover the impact of disease and treatment on cognition more comprehensively. In this chapter, we focus on MRI measures related to synaptic function, reserve and clearance. We discuss how brain reserve, cognitive reserve and vascular reserve can be captured with advanced MRI and may shed light on the observed disparities between MRI-based atrophy and cognition. We then elaborate on how advanced MRI readouts currently enable us to tap into brain waste clearance. Taken together, we highlight that advanced MRI can contribute to a comprehensive assessment of how Alzheimer's disease impacts on the brain physiology beyond atrophy over time.
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000278927 7001_ $$0P:(DE-2719)9001989$$aBernal, Jose$$b1$$eLast author$$udzne
000278927 773__ $$a10.1016/B978-0-12-822240-9.00015-6
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000278927 9141_ $$y2025
000278927 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x0
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