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@INBOOK{Dzel:278927,
      author       = {Düzel, Emrah and Bernal, Jose},
      title        = {{A}dvances in imaging},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00653},
      pages        = {123 - 148},
      year         = {2025},
      comment      = {Early Detection in Alzheimer' s Disease / Düzel, Emrah ; :
                      Elsevier, 2025, ; ISBN: 9780128222409 ;
                      doi:10.1016/B978-0-12-822240-9.00015-6},
      booktitle     = {Early Detection in Alzheimer' s
                       Disease / Düzel, Emrah ; : Elsevier,
                       2025, ; ISBN: 9780128222409 ;
                       doi:10.1016/B978-0-12-822240-9.00015-6},
      abstract     = {Advances in magnetic resonance imaging (MRI) technology
                      have profoundly transformed our ability to accurately
                      measure brain structures and conduct long-term monitoring of
                      their changes, elucidating the intricate interplay between
                      brain structure, cognition, and health status in response to
                      aging and neurodegeneration. To date, it is clear that
                      volumetric MRI measurements explain a significant portion of
                      the heterogeneity in individuals' cognitive performance and
                      reflect the impact of pathology on the brain. However,
                      recent findings from disease-modifying treatments (DMTs)
                      have demonstrated that slowing cognitive decline does not
                      equate to slowing of brain atrophy. This indicates that we
                      need other measures than atrophy over time to uncover the
                      impact of disease and treatment on cognition more
                      comprehensively. In this chapter, we focus on MRI measures
                      related to synaptic function, reserve and clearance. We
                      discuss how brain reserve, cognitive reserve and vascular
                      reserve can be captured with advanced MRI and may shed light
                      on the observed disparities between MRI-based atrophy and
                      cognition. We then elaborate on how advanced MRI readouts
                      currently enable us to tap into brain waste clearance. Taken
                      together, we highlight that advanced MRI can contribute to a
                      comprehensive assessment of how Alzheimer's disease impacts
                      on the brain physiology beyond atrophy over time.},
      cin          = {AG Düzel},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1016/B978-0-12-822240-9.00015-6},
      url          = {https://pub.dzne.de/record/278927},
}