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@ARTICLE{Angel:278931,
      author       = {Angel, Del and Tsutiya, Atsuhiro and Hayani, Hussam and
                      Madencioglu, Deniz and Kul, Emre and Caliskan, Gürsel and
                      Demiray, Yunus Emre and Dityatev, Alexander and Stork,
                      Oliver},
      title        = {{T}he {S}erine/{T}hreonine {K}inase {NDR}2 {R}egulates
                      {I}ntegrin {S}ignaling, {S}ynapse {F}ormation, and
                      {S}ynaptic {P}lasticity in the {H}ippocampus.},
      journal      = {Journal of neurochemistry},
      volume       = {169},
      number       = {6},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-00657},
      pages        = {e70094},
      year         = {2025},
      abstract     = {Nuclear Dbf2-related (NDR) kinases are core components of
                      the Hippo pathway, which controls neuronal polarity and
                      neurite growth in the central nervous system (CNS). NDR2 is
                      the principal NDR kinase in the mouse CNS, where it has been
                      shown to regulate integrin-dependent dendritic branching as
                      well as growth and plasticity in hippocampal mossy fibers.
                      Given the well-established involvement of integrins in
                      plasticity, we hypothesized that NDR2 might regulate synapse
                      formation and plasticity through integrin-mediated
                      mechanisms. In this study, using constitutive NDR2 null
                      mutant mice, we demonstrate that Ndr2 deficiency leads to a
                      reduction of T788/789 phosphorylated β1 integrin expression
                      at synaptic sites both in the hippocampal area CA1 and in
                      primary hippocampal neurons in vitro. This reduction is
                      associated with decreased synaptic density in both
                      conditions and accompanied by reduced long-term potentiation
                      in the synapses between Schaffer collaterals/commissural
                      fibers and CA1 pyramidal cells, which could be restored by
                      activation of integrins with an
                      arginine-glycine-aspartate-containing peptide, as well as
                      with mild spatial memory deficits. Together, our results
                      suggest that NDR2 is involved in integrin-dependent synapse
                      formation and plasticity in the mouse hippocampus.},
      keywords     = {Animals / Protein Serine-Threonine Kinases: genetics /
                      Protein Serine-Threonine Kinases: physiology / Protein
                      Serine-Threonine Kinases: metabolism / Neuronal Plasticity:
                      physiology / Synapses: physiology / Mice / Hippocampus:
                      cytology / Hippocampus: physiology / Hippocampus: metabolism
                      / Signal Transduction: physiology / Mice, Knockout / Mice,
                      Inbred C57BL / Cells, Cultured / Male / Integrins:
                      metabolism / Integrin beta1: metabolism / Neurons /
                      hippocampus (Other) / integrin signaling (Other) / nuclear
                      DBF2‐related kinase 2 (Other) / plasticity (Other) /
                      spatial memory (Other) / synapses (Other) / Protein
                      Serine-Threonine Kinases (NLM Chemicals) / Integrins (NLM
                      Chemicals) / Integrin beta1 (NLM Chemicals)},
      cin          = {AG Dityatev},
      ddc          = {610},
      cid          = {I:(DE-2719)1310007},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40439020},
      pmc          = {pmc:PMC12120816},
      doi          = {10.1111/jnc.70094},
      url          = {https://pub.dzne.de/record/278931},
}