Home > Publications Database > The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus. > print

001     278931
005     20250604100732.0
024 7 _ |a 10.1111/jnc.70094
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024 7 _ |a 1471-4159
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037 _ _ |a DZNE-2025-00657
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Angel, Del
|0 0000-0002-8669-0473
|b 0
245 _ _ |a The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus.
260 _ _ |a Oxford
|c 2025
|b Wiley-Blackwell
336 7 _ |a article
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520 _ _ |a Nuclear Dbf2-related (NDR) kinases are core components of the Hippo pathway, which controls neuronal polarity and neurite growth in the central nervous system (CNS). NDR2 is the principal NDR kinase in the mouse CNS, where it has been shown to regulate integrin-dependent dendritic branching as well as growth and plasticity in hippocampal mossy fibers. Given the well-established involvement of integrins in plasticity, we hypothesized that NDR2 might regulate synapse formation and plasticity through integrin-mediated mechanisms. In this study, using constitutive NDR2 null mutant mice, we demonstrate that Ndr2 deficiency leads to a reduction of T788/789 phosphorylated β1 integrin expression at synaptic sites both in the hippocampal area CA1 and in primary hippocampal neurons in vitro. This reduction is associated with decreased synaptic density in both conditions and accompanied by reduced long-term potentiation in the synapses between Schaffer collaterals/commissural fibers and CA1 pyramidal cells, which could be restored by activation of integrins with an arginine-glycine-aspartate-containing peptide, as well as with mild spatial memory deficits. Together, our results suggest that NDR2 is involved in integrin-dependent synapse formation and plasticity in the mouse hippocampus.
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650 _ 7 |a hippocampus
|2 Other
650 _ 7 |a integrin signaling
|2 Other
650 _ 7 |a nuclear DBF2‐related kinase 2
|2 Other
650 _ 7 |a plasticity
|2 Other
650 _ 7 |a spatial memory
|2 Other
650 _ 7 |a synapses
|2 Other
650 _ 7 |a Protein Serine-Threonine Kinases
|0 EC 2.7.11.1
|2 NLM Chemicals
650 _ 7 |a Integrins
|2 NLM Chemicals
650 _ 7 |a Integrin beta1
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Protein Serine-Threonine Kinases: genetics
|2 MeSH
650 _ 2 |a Protein Serine-Threonine Kinases: physiology
|2 MeSH
650 _ 2 |a Protein Serine-Threonine Kinases: metabolism
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Synapses: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Hippocampus: cytology
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction: physiology
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Cells, Cultured
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Integrins: metabolism
|2 MeSH
650 _ 2 |a Integrin beta1: metabolism
|2 MeSH
650 _ 2 |a Neurons
|2 MeSH
700 1 _ |a Tsutiya, Atsuhiro
|b 1
700 1 _ |a Hayani, Hussam
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700 1 _ |a Madencioglu, Deniz
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700 1 _ |a Kul, Emre
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700 1 _ |a Caliskan, Gürsel
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700 1 _ |a Demiray, Yunus Emre
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700 1 _ |a Dityatev, Alexander
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700 1 _ |a Stork, Oliver
|0 0000-0003-4285-7507
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773 _ _ |a 10.1111/jnc.70094
|g Vol. 169, no. 6, p. e70094
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