TY  - JOUR
AU  - Yang, Xingwang
AU  - Zeng, Weiyi
AU  - Estrada Leon, Edgar Santiago
AU  - Breteler, Monique
AU  - Aziz, N. Ahmad
TI  - Association between brain structure and fine motor function: findings from the population-based Rhineland Study.
JO  - EBioMedicine
VL  - 116
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2025-00658
SP  - 105771
PY  - 2025
AB  - Although an association between brain atrophy and decreased fine motor function has been reported, results from previous studies are inconsistent. We aimed to investigate whether decreased fine motor function is reflected in age- and sex-associated changes in brain structure across the adult lifespan in a large community dwelling cohort study.The Rhineland Study is an on-going population-based prospective cohort study in Bonn, Germany. We used cross-sectional data from the first 8318 participants of the Rhineland Study (age range: 30-95 years), who underwent baseline assessments between March 2016 and November 2022. A digital spiral drawing test was utilised to evaluate fine motor skills: tracing precision (deviation area), tracing velocity, and frequency of tremor. Brain volumetric and cortical thickness measures were obtained from 3T T1 MRI scans. The relationship between brain structure and fine motor function was examined with multivariable regression, while adjusting for age, sex, education, smoking status and grip strength.Smaller volumes and/or thinner cortices in several brain regions were associated with decreased tracing precision (higher tracing deviation area) and higher tremor frequency, including total brain volume (tracing area: β = -0.108, 95
KW  - Brain imaging analysis (Other)
KW  - Brain structure (Other)
KW  - Fine motor function (Other)
KW  - MRI (Other)
KW  - Spiral drawing test (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40403697
DO  - DOI:10.1016/j.ebiom.2025.105771
UR  - https://pub.dzne.de/record/278932
ER  -