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000279048 0247_ $$2doi$$a10.1016/j.nlm.2025.108036
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000279048 1001_ $$aBalmer, Greta Leonore$$b0
000279048 245__ $$aEngrams across diseases: Different pathologies - unifying mechanisms?
000279048 260__ $$aOrlando, Fla.$$bAcademic Press$$c2025
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000279048 520__ $$aMemories are our reservoir of knowledge and thus, are crucial for guiding decisions and defining our self. The physical correlate of a memory in the brain is termed an engram and since decades helps researchers to elucidate the intricate nature of our imprinted experiences and knowledge. Given the importance that memories have for our lives, their impairment can present a tremendous burden. In this review we aim to discuss engram malfunctioning across diseases, covering dementia-associated pathologies, epilepsy, chronic pain and psychiatric disorders. Current neuroscientific tools allow to witness the emergence and fate of engram cells and enable their manipulation. We further suggest that specific mechanisms of mnemonic malfunction can be derived from engram cell readouts. While depicting the way diseases act on the mnemonic component - specifically, on the cellular engram - we emphasize a differentiation between forms of amnesia and hypermnesia. Finally, we highlight commonalities and distinctions of engram impairments on the cellular level across diseases independent of their pathogenic origins and discuss prospective therapeutic measures.
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000279048 650_7 $$2Other$$aAlzheimer’s disease
000279048 650_7 $$2Other$$aEngram cell
000279048 650_7 $$2Other$$aFragile-X-Syndrome
000279048 650_7 $$2Other$$aParkinson’s disease
000279048 650_7 $$2Other$$aRett syndrome
000279048 650_7 $$2Other$$aaddiction
000279048 650_7 $$2Other$$aamnesia, hypermnesia
000279048 650_7 $$2Other$$achronic pain
000279048 650_7 $$2Other$$aepilepsy
000279048 650_7 $$2Other$$amajor depressive disorder
000279048 650_7 $$2Other$$amnemonic malfunction
000279048 650_7 $$2Other$$apost-traumatic stress disorder
000279048 650_7 $$2Other$$atranslation
000279048 650_2 $$2MeSH$$aHumans
000279048 650_2 $$2MeSH$$aBrain: physiopathology
000279048 650_2 $$2MeSH$$aBrain: physiology
000279048 650_2 $$2MeSH$$aMental Disorders: physiopathology
000279048 650_2 $$2MeSH$$aMemory: physiology
000279048 650_2 $$2MeSH$$aEpilepsy: physiopathology
000279048 650_2 $$2MeSH$$aChronic Pain: physiopathology
000279048 650_2 $$2MeSH$$aAnimals
000279048 650_2 $$2MeSH$$aDementia: physiopathology
000279048 7001_ $$aGuha, Shuvrangshu$$b1
000279048 7001_ $$0P:(DE-2719)2810397$$aPoll, Stefanie$$b2$$eLast author$$udzne
000279048 773__ $$0PERI:(DE-600)1471414-0$$a10.1016/j.nlm.2025.108036$$gVol. 219, p. 108036 -$$p108036$$tNeurobiology of learning and memory$$v219$$x1074-7427$$y2025
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