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@ARTICLE{Balmer:279048,
      author       = {Balmer, Greta Leonore and Guha, Shuvrangshu and Poll,
                      Stefanie},
      title        = {{E}ngrams across diseases: {D}ifferent pathologies -
                      unifying mechanisms?},
      journal      = {Neurobiology of learning and memory},
      volume       = {219},
      issn         = {1074-7427},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2025-00678},
      pages        = {108036},
      year         = {2025},
      abstract     = {Memories are our reservoir of knowledge and thus, are
                      crucial for guiding decisions and defining our self. The
                      physical correlate of a memory in the brain is termed an
                      engram and since decades helps researchers to elucidate the
                      intricate nature of our imprinted experiences and knowledge.
                      Given the importance that memories have for our lives, their
                      impairment can present a tremendous burden. In this review
                      we aim to discuss engram malfunctioning across diseases,
                      covering dementia-associated pathologies, epilepsy, chronic
                      pain and psychiatric disorders. Current neuroscientific
                      tools allow to witness the emergence and fate of engram
                      cells and enable their manipulation. We further suggest that
                      specific mechanisms of mnemonic malfunction can be derived
                      from engram cell readouts. While depicting the way diseases
                      act on the mnemonic component - specifically, on the
                      cellular engram - we emphasize a differentiation between
                      forms of amnesia and hypermnesia. Finally, we highlight
                      commonalities and distinctions of engram impairments on the
                      cellular level across diseases independent of their
                      pathogenic origins and discuss prospective therapeutic
                      measures.},
      subtyp        = {Review Article},
      keywords     = {Humans / Brain: physiopathology / Brain: physiology /
                      Mental Disorders: physiopathology / Memory: physiology /
                      Epilepsy: physiopathology / Chronic Pain: physiopathology /
                      Animals / Dementia: physiopathology / Alzheimer’s disease
                      (Other) / Engram cell (Other) / Fragile-X-Syndrome (Other) /
                      Parkinson’s disease (Other) / Rett syndrome (Other) /
                      addiction (Other) / amnesia, hypermnesia (Other) / chronic
                      pain (Other) / epilepsy (Other) / major depressive disorder
                      (Other) / mnemonic malfunction (Other) / post-traumatic
                      stress disorder (Other) / translation (Other)},
      cin          = {AG Fuhrmann},
      ddc          = {570},
      cid          = {I:(DE-2719)1011004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40023216},
      doi          = {10.1016/j.nlm.2025.108036},
      url          = {https://pub.dzne.de/record/279048},
}