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001     279048
005     20250713001355.0
024 7 _ |a 10.1016/j.nlm.2025.108036
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024 7 _ |a pmid:40023216
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024 7 _ |a 1074-7427
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024 7 _ |a 1095-9564
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037 _ _ |a DZNE-2025-00678
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Balmer, Greta Leonore
|b 0
245 _ _ |a Engrams across diseases: Different pathologies - unifying mechanisms?
260 _ _ |a Orlando, Fla.
|c 2025
|b Academic Press
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520 _ _ |a Memories are our reservoir of knowledge and thus, are crucial for guiding decisions and defining our self. The physical correlate of a memory in the brain is termed an engram and since decades helps researchers to elucidate the intricate nature of our imprinted experiences and knowledge. Given the importance that memories have for our lives, their impairment can present a tremendous burden. In this review we aim to discuss engram malfunctioning across diseases, covering dementia-associated pathologies, epilepsy, chronic pain and psychiatric disorders. Current neuroscientific tools allow to witness the emergence and fate of engram cells and enable their manipulation. We further suggest that specific mechanisms of mnemonic malfunction can be derived from engram cell readouts. While depicting the way diseases act on the mnemonic component - specifically, on the cellular engram - we emphasize a differentiation between forms of amnesia and hypermnesia. Finally, we highlight commonalities and distinctions of engram impairments on the cellular level across diseases independent of their pathogenic origins and discuss prospective therapeutic measures.
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650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Engram cell
|2 Other
650 _ 7 |a Fragile-X-Syndrome
|2 Other
650 _ 7 |a Parkinson’s disease
|2 Other
650 _ 7 |a Rett syndrome
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650 _ 7 |a addiction
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650 _ 7 |a amnesia, hypermnesia
|2 Other
650 _ 7 |a chronic pain
|2 Other
650 _ 7 |a epilepsy
|2 Other
650 _ 7 |a major depressive disorder
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650 _ 7 |a mnemonic malfunction
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650 _ 7 |a post-traumatic stress disorder
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650 _ 7 |a translation
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Brain: physiopathology
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650 _ 2 |a Brain: physiology
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650 _ 2 |a Mental Disorders: physiopathology
|2 MeSH
650 _ 2 |a Memory: physiology
|2 MeSH
650 _ 2 |a Epilepsy: physiopathology
|2 MeSH
650 _ 2 |a Chronic Pain: physiopathology
|2 MeSH
650 _ 2 |a Animals
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650 _ 2 |a Dementia: physiopathology
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700 1 _ |a Guha, Shuvrangshu
|b 1
700 1 _ |a Poll, Stefanie
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773 _ _ |a 10.1016/j.nlm.2025.108036
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|t Neurobiology of learning and memory
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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