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000279178 1001_ $$0P:(DE-2719)9001827$$aLiebscher, Maxie$$b0$$eFirst author$$udzne
000279178 245__ $$aResting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation
000279178 260__ $$aAmsterdam$$bElsevier$$c2025
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000279178 520__ $$aBackground:Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.Methods:Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.Results:Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms.Conclusions:Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection.
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000279178 7001_ $$aLaubacher, Claire$$b1
000279178 7001_ $$aImhoff-Smith, Theodore P.$$b2
000279178 7001_ $$aBirn, Rasmus M.$$b3
000279178 7001_ $$aKlaus, Danika R.$$b4
000279178 7001_ $$aFrye, Corrina J.$$b5
000279178 7001_ $$aBusse, William W.$$b6
000279178 7001_ $$00000-0001-8432-9011$$aRosenkranz, Melissa A.$$b7
000279178 773__ $$0PERI:(DE-600)3094992-0$$a10.1016/j.bpsgos.2025.100527$$gVol. 5, no. 5, p. 100527 -$$n5$$p100527$$tBiological psychiatry: global open science$$v5$$x2667-1743$$y2025
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