TY  - JOUR
AU  - Liebscher, Maxie
AU  - Laubacher, Claire
AU  - Imhoff-Smith, Theodore P.
AU  - Birn, Rasmus M.
AU  - Klaus, Danika R.
AU  - Frye, Corrina J.
AU  - Busse, William W.
AU  - Rosenkranz, Melissa A.
TI  - Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation
JO  - Biological psychiatry: global open science
VL  - 5
IS  - 5
SN  - 2667-1743
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2025-00706
SP  - 100527
PY  - 2025
AB  - Background:Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.Methods:Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.Results:Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms.Conclusions:Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.bpsgos.2025.100527
UR  - https://pub.dzne.de/record/279178
ER  -