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@ARTICLE{Liebscher:279178,
      author       = {Liebscher, Maxie and Laubacher, Claire and Imhoff-Smith,
                      Theodore P. and Birn, Rasmus M. and Klaus, Danika R. and
                      Frye, Corrina J. and Busse, William W. and Rosenkranz,
                      Melissa A.},
      title        = {{R}esting-{S}tate {N}etwork {D}ynamics in {A}sthma:
                      {I}nterplay {B}etween {D}epressive {S}ymptoms and {A}irway
                      {I}nflammation},
      journal      = {Biological psychiatry: global open science},
      volume       = {5},
      number       = {5},
      issn         = {2667-1743},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00706},
      pages        = {100527},
      year         = {2025},
      abstract     = {Asthma and depression frequently co-occur, potentially
                      worsening each other's symptoms. The salience network (SN)
                      may play a key role in this link, but the roles of the
                      default mode network (DMN) and frontoparietal network (FPN),
                      as outlined in the triple network theory, remain unclear in
                      the asthma-depression connection. This longitudinal study
                      investigated pre-post changes in graph-theory metrics within
                      and between the 3 networks in individuals with asthma and
                      how these relate to depressive symptoms.Twenty-four
                      individuals with asthma underwent functional magnetic
                      resonance imaging scans pre- and postsegmental allergen
                      challenge. Depressive symptoms were assessed at baseline
                      using the Beck Depression Inventory. Changes in graph-theory
                      metrics were analyzed using region-of-interest (ROI)-to-ROI
                      analyses, controlling for sex.Allergen challenge led to
                      changes in network properties. Within-network analyses
                      showed decreased degree centrality (β = 0.50, false
                      discovery rate-corrected p [p FDR] = .004) and betweenness
                      centrality (β = 0.10, p FDR = .025) of the posterior
                      cingulate cortex (DMN) and reduced degree centrality of the
                      anterior cingulate cortex (SN), which correlated with
                      depressive symptoms (β = 0.05, p FDR = .017).
                      Between-network analyses showed reduced closeness centrality
                      in the bilateral lateral parietal during SN-DMN interactions
                      (right: β = 0.23, p FDR = .010; left: β = 0.23, p FDR =
                      .013) and increased degree centrality in the left posterior
                      parietal cortex during SN-FPN interactions (β = -0.10, p
                      FDR = .038), which correlated with depressive
                      symptoms.Allergen challenge alters graph-theory metrics
                      within and between resting-state networks, with changes
                      linked to depression symptoms. Findings highlight the SN's
                      critical role in network switching and its vulnerability to
                      inflammation in asthma-depression connection.},
      cin          = {AG Wirth},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40546324},
      pmc          = {pmc:PMC12180996},
      doi          = {10.1016/j.bpsgos.2025.100527},
      url          = {https://pub.dzne.de/record/279178},
}