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@ARTICLE{Liebscher:279178,
      author       = {Liebscher, Maxie and Laubacher, Claire and Imhoff-Smith,
                      Theodore P. and Birn, Rasmus M. and Klaus, Danika R. and
                      Frye, Corrina J. and Busse, William W. and Rosenkranz,
                      Melissa A.},
      title        = {{R}esting-{S}tate {N}etwork {D}ynamics in {A}sthma:
                      {I}nterplay {B}etween {D}epressive {S}ymptoms and {A}irway
                      {I}nflammation},
      journal      = {Biological psychiatry: global open science},
      volume       = {5},
      number       = {5},
      issn         = {2667-1743},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00706},
      pages        = {100527},
      year         = {2025},
      abstract     = {Background:Asthma and depression frequently co-occur,
                      potentially worsening each other’s symptoms. The salience
                      network (SN) may play a key role in this link, but the roles
                      of the default mode network (DMN) and frontoparietal network
                      (FPN), as outlined in the triple network theory, remain
                      unclear in the asthma-depression connection. This
                      longitudinal study investigated pre-post changes in
                      graph-theory metrics within and between the 3 networks in
                      individuals with asthma and how these relate to depressive
                      symptoms.Methods:Twenty-four individuals with asthma
                      underwent functional magnetic resonance imaging scans pre-
                      and postsegmental allergen challenge. Depressive symptoms
                      were assessed at baseline using the Beck Depression
                      Inventory. Changes in graph-theory metrics were analyzed
                      using region-of-interest (ROI)-to-ROI analyses, controlling
                      for sex.Results:Allergen challenge led to changes in network
                      properties. Within-network analyses showed decreased degree
                      centrality (β = 0.50, false discovery rate–corrected p
                      [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR =
                      .025) of the posterior cingulate cortex (DMN) and reduced
                      degree centrality of the anterior cingulate cortex (SN),
                      which correlated with depressive symptoms (β = 0.05, pFDR =
                      .017). Between-network analyses showed reduced closeness
                      centrality in the bilateral lateral parietal during SN-DMN
                      interactions (right: β = 0.23, pFDR = .010; left: β =
                      0.23, pFDR = .013) and increased degree centrality in the
                      left posterior parietal cortex during SN-FPN interactions
                      (β = −0.10, pFDR = .038), which correlated with
                      depressive symptoms.Conclusions:Allergen challenge alters
                      graph-theory metrics within and between resting-state
                      networks, with changes linked to depression symptoms.
                      Findings highlight the SN’s critical role in network
                      switching and its vulnerability to inflammation in
                      asthma-depression connection.},
      cin          = {AG Wirth},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.bpsgos.2025.100527},
      url          = {https://pub.dzne.de/record/279178},
}