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| 001 | 279178 | ||
| 005 | 20250709100936.0 | ||
| 024 | 7 | _ | |a 10.1016/j.bpsgos.2025.100527 |2 doi |
| 037 | _ | _ | |a DZNE-2025-00706 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Liebscher, Maxie |0 P:(DE-2719)9001827 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| 260 | _ | _ | |a Amsterdam |c 2025 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Background:Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.Methods:Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.Results:Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms.Conclusions:Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection. |
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| 700 | 1 | _ | |a Laubacher, Claire |b 1 |
| 700 | 1 | _ | |a Imhoff-Smith, Theodore P. |b 2 |
| 700 | 1 | _ | |a Birn, Rasmus M. |b 3 |
| 700 | 1 | _ | |a Klaus, Danika R. |b 4 |
| 700 | 1 | _ | |a Frye, Corrina J. |b 5 |
| 700 | 1 | _ | |a Busse, William W. |b 6 |
| 700 | 1 | _ | |a Rosenkranz, Melissa A. |0 0000-0001-8432-9011 |b 7 |
| 773 | _ | _ | |a 10.1016/j.bpsgos.2025.100527 |g Vol. 5, no. 5, p. 100527 - |0 PERI:(DE-600)3094992-0 |n 5 |p 100527 |t Biological psychiatry: global open science |v 5 |y 2025 |x 2667-1743 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/279178/files/DZNE-2025-00706%20SUP.zip |
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