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000279183 1001_ $$aBruin, Willem B.$$b0
000279183 245__ $$aBrain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning
000279183 260__ $$aLondon$$bNature Publishing Group UK$$c2024
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000279183 520__ $$aNeuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case–control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10–25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but also transdiagnostically for all anxiety disorders when patients were subgrouped according to their sex, medication status and symptom severity (area under the receiver operating characteristic curve, 0.59–0.63). Classifications were driven by neuroanatomical features (cortical thickness, cortical surface area and subcortical volumes) in fronto-striato-limbic and temporoparietal regions. This benchmark study within a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.
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000279183 7001_ $$aZhutovsky, Paul$$b1
000279183 7001_ $$avan Wingen, Guido A.$$b2
000279183 7001_ $$aBas-Hoogendam, Janna Marie$$b3
000279183 7001_ $$aGroenewold, Nynke A.$$b4
000279183 7001_ $$aHilbert, Kevin$$b5
000279183 7001_ $$aWinkler, Anderson M.$$b6
000279183 7001_ $$aZugman, Andre$$b7
000279183 7001_ $$aAgosta, Federica$$b8
000279183 7001_ $$aÅhs, Fredrik$$b9
000279183 7001_ $$aAndreescu, Carmen$$b10
000279183 7001_ $$aAntonacci, Chase$$b11
000279183 7001_ $$aAsami, Takeshi$$b12
000279183 7001_ $$aAssaf, Michal$$b13
000279183 7001_ $$aBarber, Jacques P.$$b14
000279183 7001_ $$aBauer, Jochen$$b15
000279183 7001_ $$aBavdekar, Shreya Y.$$b16
000279183 7001_ $$aBeesdo-Baum, Katja$$b17
000279183 7001_ $$aBenedetti, Francesco$$b18
000279183 7001_ $$aBernstein, Rachel$$b19
000279183 7001_ $$aBjörkstrand, Johannes$$b20
000279183 7001_ $$aBlair, Robert J.$$b21
000279183 7001_ $$aBlair, Karina S.$$b22
000279183 7001_ $$aBlanco-Hinojo, Laura$$b23
000279183 7001_ $$aBöhnlein, Joscha$$b24
000279183 7001_ $$aBrambilla, Paolo$$b25
000279183 7001_ $$aBressan, Rodrigo A.$$b26
000279183 7001_ $$aBreuer, Fabian$$b27
000279183 7001_ $$aCano, Marta$$b28
000279183 7001_ $$aCanu, Elisa$$b29
000279183 7001_ $$aCardinale, Elise M.$$b30
000279183 7001_ $$aCardoner, Narcís$$b31
000279183 7001_ $$aCividini, Camilla$$b32
000279183 7001_ $$aCremers, Henk$$b33
000279183 7001_ $$aDannlowski, Udo$$b34
000279183 7001_ $$aDiefenbach, Gretchen J.$$b35
000279183 7001_ $$aDomschke, Katharina$$b36
000279183 7001_ $$aDoruyter, Alexander G. G.$$b37
000279183 7001_ $$aDresler, Thomas$$b38
000279183 7001_ $$aErhardt, Angelika$$b39
000279183 7001_ $$aFilippi, Massimo$$b40
000279183 7001_ $$aFonzo, Gregory A.$$b41
000279183 7001_ $$aFreitag, Gabrielle F.$$b42
000279183 7001_ $$aFurmark, Tomas$$b43
000279183 7001_ $$aGe, Tian$$b44
000279183 7001_ $$aGerber, Andrew J.$$b45
000279183 7001_ $$aGosnell, Savannah N.$$b46
000279183 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans$$b47$$udzne
000279183 7001_ $$aGrotegerd, Dominik$$b48
000279183 7001_ $$aGur, Ruben C.$$b49
000279183 7001_ $$aGur, Raquel E.$$b50
000279183 7001_ $$aHamm, Alfons O.$$b51
000279183 7001_ $$aHan, Laura K. M.$$b52
000279183 7001_ $$aHarper, Jennifer C.$$b53
000279183 7001_ $$aHarrewijn, Anita$$b54
000279183 7001_ $$aHeeren, Alexandre$$b55
000279183 7001_ $$aHofmann, David$$b56
000279183 7001_ $$aJackowski, Andrea P.$$b57
000279183 7001_ $$aJahanshad, Neda$$b58
000279183 7001_ $$aJett, Laura$$b59
000279183 7001_ $$aKaczkurkin, Antonia N.$$b60
000279183 7001_ $$aKhosravi, Parmis$$b61
000279183 7001_ $$aKingsley, Ellen N.$$b62
000279183 7001_ $$aKircher, Tilo$$b63
000279183 7001_ $$aKostic, Milutin$$b64
000279183 7001_ $$aLarsen, Bart$$b65
000279183 7001_ $$aLee, Sang-Hyuk$$b66
000279183 7001_ $$aLeehr, Elisabeth J.$$b67
000279183 7001_ $$aLeibenluft, Ellen$$b68
000279183 7001_ $$aLochner, Christine$$b69
000279183 7001_ $$aLui, Su$$b70
000279183 7001_ $$aMaggioni, Eleonora$$b71
000279183 7001_ $$aManfro, Gisele G.$$b72
000279183 7001_ $$aMånsson, Kristoffer N. T.$$b73
000279183 7001_ $$aMarino, Claire E.$$b74
000279183 7001_ $$aMeeten, Frances$$b75
000279183 7001_ $$aMilrod, Barbara$$b76
000279183 7001_ $$aJovanovic, Ana Munjiza$$b77
000279183 7001_ $$aMwangi, Benson$$b78
000279183 7001_ $$aMyers, Michael J.$$b79
000279183 7001_ $$aNeufang, Susanne$$b80
000279183 7001_ $$aNielsen, Jared A.$$b81
000279183 7001_ $$aOhrmann, Patricia A.$$b82
000279183 7001_ $$aOttaviani, Cristina$$b83
000279183 7001_ $$aPaulus, Martin P.$$b84
000279183 7001_ $$aPerino, Michael T.$$b85
000279183 7001_ $$aPhan, K. Luan$$b86
000279183 7001_ $$aPoletti, Sara$$b87
000279183 7001_ $$aPorta-Casteràs, Daniel$$b88
000279183 7001_ $$aPujol, Jesus$$b89
000279183 7001_ $$aReinecke, Andrea$$b90
000279183 7001_ $$aRinglein, Grace V.$$b91
000279183 7001_ $$aRjabtsenkov, Pavel$$b92
000279183 7001_ $$aRoelofs, Karin$$b93
000279183 7001_ $$aSalas, Ramiro$$b94
000279183 7001_ $$aSalum, Giovanni A.$$b95
000279183 7001_ $$aSatterthwaite, Theodore D.$$b96
000279183 7001_ $$aSchrammen, Elisabeth$$b97
000279183 7001_ $$aSindermann, Lisa$$b98
000279183 7001_ $$aSmoller, Jordan W.$$b99
000279183 7001_ $$aSoares, Jair C.$$b100
000279183 7001_ $$aStark, Rudolf$$b101
000279183 7001_ $$aStein, Frederike$$b102
000279183 7001_ $$aStraube, Thomas$$b103
000279183 7001_ $$aStraube, Benjamin$$b104
000279183 7001_ $$aStrawn, Jeffrey R.$$b105
000279183 7001_ $$aSuarez-Jimenez, Benjamin$$b106
000279183 7001_ $$aSylvester, Chad M.$$b107
000279183 7001_ $$aTalati, Ardesheer$$b108
000279183 7001_ $$aThomopoulos, Sophia I.$$b109
000279183 7001_ $$aTükel, Raşit$$b110
000279183 7001_ $$avan Nieuwenhuizen, Helena$$b111
000279183 7001_ $$aWerwath, Kathryn$$b112
000279183 7001_ $$0P:(DE-2719)2810491$$aWittfeld, Katharina$$b113$$udzne
000279183 7001_ $$aWright, Barry$$b114
000279183 7001_ $$aWu, Mon-Ju$$b115
000279183 7001_ $$aYang, Yunbo$$b116
000279183 7001_ $$aZilverstand, Anna$$b117
000279183 7001_ $$aZwanzger, Peter$$b118
000279183 7001_ $$aBlackford, Jennifer U.$$b119
000279183 7001_ $$aAvery, Suzanne N.$$b120
000279183 7001_ $$aClauss, Jacqueline A.$$b121
000279183 7001_ $$aLueken, Ulrike$$b122
000279183 7001_ $$aThompson, Paul M.$$b123
000279183 7001_ $$aPine, Daniel S.$$b124
000279183 7001_ $$aStein, Dan J.$$b125
000279183 7001_ $$avan der Wee, Nic J. A.$$b126
000279183 7001_ $$aVeltman, Dick J.$$b127
000279183 7001_ $$00000-0003-2040-4881$$aAghajani, Moji$$b128
000279183 773__ $$0PERI:(DE-600)3123130-5$$a10.1038/s44220-023-00173-2$$gVol. 2, no. 1, p. 104 - 118$$n1$$p104 - 118$$tNature Mental Health$$v2$$x2731-6076$$y2024
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