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| Home > Publications Database > Feasibility of an App-Assisted and Home-Based Video Version of the Timed Up and Go Test for Patients with Parkinson Disease: vTUG. > print |
| 001 | 279196 | ||
| 005 | 20250709100937.0 | ||
| 024 | 7 | _ | |a 10.3390/jcm14113769 |2 doi |
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| 037 | _ | _ | |a DZNE-2025-00724 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Grobe-Einsler, Marcus |0 P:(DE-2719)9001510 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Feasibility of an App-Assisted and Home-Based Video Version of the Timed Up and Go Test for Patients with Parkinson Disease: vTUG. |
| 260 | _ | _ | |a Basel |c 2025 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1751974579_26500 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Background: Parkinson Disease (PD) is a progressive neurodegenerative disorder. Current therapeutic trials investigate treatments that can potentially modify the disease course. Testing their efficiency requires outcome assessments that are relevant to patients' daily lives, which include gait and balance. Home-based examinations may enhance patient compliance and, in addition, produce more reliable results by assessing patients more regularly in their familiar surroundings. Objective: The objective of this pilot study was to assess the feasibility of a home-based outcome assessment designed to video record the Timed up and Go (vTUG) test via a study-specific smartphone app for patients with PD. Methods: 28 patients were recruited and asked to perform at home each week a set of three consecutive vTUG tests, over a period of 12 weeks using an app. The videos were subjected to a manual review to ascertain the durations of the individual vTUG phases, as well as to identify any errors or deviations in the setup that might have influenced the result. To evaluate the usability and user-friendliness of the vTUG and app, the System Usability Scale (SUS) and User Experience Questionnaire (UEQ) were administered to patients at the study end. Results: 19 patients completed the 12-week study, 17 of which recorded 10 videos or more. A total of 706 vTUGs with complete timings were recorded. Random Forest Regression yielded 'time to walk up' as the most important segment of the vTUG for predicting the total time. Variance of vTUG total time was significantly higher between weeks than it was between the three consecutive vTUGs at one time point [F(254,23) = 6.50, p < 0.001]. The correlation between vTUG total time and UPDRS III total score was weak (r = 0.24). The correlation between vTUG and a derived gait subscore (UPDRS III items 9-13) was moderate (r = 0.59). A linear mixed-effects model revealed a significant effect of patient-reported motion status on vTUG total time. Including additional variables such as UPDRS III gait subscore, footwear and chairs used further improved the model fit. Conclusions: Assessment of gait and balance by home-based vTUG is feasible. Factors influencing the read-out were identified and could be better controlled for future use and longitudinal trials. |
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| 650 | _ | 7 | |a digital biomarkers |2 Other |
| 650 | _ | 7 | |a home monitoring |2 Other |
| 650 | _ | 7 | |a motor assessments |2 Other |
| 700 | 1 | _ | |a Gerdes, Anna |b 1 |
| 700 | 1 | _ | |a Feige, Tim |0 P:(DE-2719)9000884 |b 2 |
| 700 | 1 | _ | |a Maas, Vivian |0 P:(DE-2719)9002174 |b 3 |u dzne |
| 700 | 1 | _ | |a Matthews, Clare |0 0000-0001-6994-3945 |b 4 |
| 700 | 1 | _ | |a Mendoza García, Alejandro |b 5 |
| 700 | 1 | _ | |a Comas Fages, Laia |b 6 |
| 700 | 1 | _ | |a Haf Davies, Elin |b 7 |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-2719)2810314 |b 8 |u dzne |
| 700 | 1 | _ | |a Falkenburger, Björn H |0 P:(DE-2719)2814178 |b 9 |e Last author |
| 770 | _ | _ | |a Digital Health Technologies in Parkinson’s Disease and Related Disorders |
| 773 | _ | _ | |a 10.3390/jcm14113769 |g Vol. 14, no. 11, p. 3769 - |0 PERI:(DE-600)2662592-1 |n 11 |p 3769 |t Journal of Clinical Medicine |v 14 |y 2025 |x 2077-0383 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/279196/files/DZNE-2025-00724.pdf |
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