%0 Journal Article
%A Soriano, Laura Del Hoyo
%A Sandkühler, Katja
%A Videla, Laura
%A Benejam, Bessy
%A Carmona-Iragui, Maria
%A Wlasich, Elisabeth
%A Kustermann, Julia
%A Barroeta, Isabel
%A Vaqué-Alcázar, Lídia
%A Rodríguez-Baz, Íñigo
%A Bejanin, Alexandre
%A Fernández, Susana
%A Arranz, Javier
%A Arriola-Infante, Jose Enrique
%A Maure-Blesa, Lucia
%A Juan, Aida San
%A Nübling, Georg
%A Wagemann, Olivia
%A Stockbauer, Anna
%A Hassenstab, Jason
%A Levin, Johannes
%A Fortea, Juan
%T Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis.
%J Alzheimer's and dementia
%V 21
%N 6
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2025-00726
%P e70307
%D 2025
%X Cut-offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut-offs across sites.This dual-center cohort study included 673 adults with mild to moderate ID at different AD stages. We assessed ID classification discrepancies across sites and the impact on Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) cut-offs for AD dementia diagnosis derived from receiver operating characteristic analysis.Inter-rater agreement for ID level classification was 95
%K Humans
%K Down Syndrome: complications
%K Intellectual Disability: diagnosis
%K Female
%K Male
%K Neuropsychological Tests: statistics & numerical data
%K Cohort Studies
%K Middle Aged
%K Aged
%K Dementia: diagnosis
%K Alzheimer Disease: diagnosis
%K AD21 (Other)
%K Alzheimer's disease (Other)
%K Cambridge Cognitive Examination for Older Adults with Down Syndrome (Other)
%K Down Alzheimer Barcelona Neuroimaging Initiative (Other)
%K Down syndrome (Other)
%K Down syndrome–associated Alzheimer's disease (Other)
%K cut‐off points (Other)
%K dementia (Other)
%K diagnostic performance (Other)
%K intellectual disability (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40528393
%2 pmc:PMC12173952
%R 10.1002/alz.70307
%U https://pub.dzne.de/record/279349