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000279349 1001_ $$00000-0003-4372-1599$$aSoriano, Laura Del Hoyo$$b0
000279349 245__ $$aDiscrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis.
000279349 260__ $$aHoboken, NJ$$bWiley$$c2025
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000279349 520__ $$aCut-offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut-offs across sites.This dual-center cohort study included 673 adults with mild to moderate ID at different AD stages. We assessed ID classification discrepancies across sites and the impact on Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) cut-offs for AD dementia diagnosis derived from receiver operating characteristic analysis.Inter-rater agreement for ID level classification was 95% within sites but 60% between sites. While CAMCOG-DS score distributions in the whole cohort were similar across sites, ID classification discrepancies caused higher cut-offs in Barcelona for mild and moderate ID compared to Munich. Applying site-specific cut-offs to another cohort reduced sensitivity and specificity.Standardizing ID classification is critical for generalizable cut-offs to accurately diagnose AD dementia based on neuropsychological assessments in DS.CAMCOG-DS cut-offs by intellectual disability level classify dementia in Down syndrome. ID classification discrepancies between sites impact CAMCOG-DS diagnostic cut-offs. Applying site-specific cut-offs to other cohorts reduces sensitivity and specificity. Standardized ID classification is essential for generalizable cognitive cut-offs. Use site-specific cut-offs until ID classification is standardized.
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000279349 650_7 $$2Other$$aAD21
000279349 650_7 $$2Other$$aAlzheimer's disease
000279349 650_7 $$2Other$$aCambridge Cognitive Examination for Older Adults with Down Syndrome
000279349 650_7 $$2Other$$aDown Alzheimer Barcelona Neuroimaging Initiative
000279349 650_7 $$2Other$$aDown syndrome
000279349 650_7 $$2Other$$aDown syndrome–associated Alzheimer's disease
000279349 650_7 $$2Other$$acut‐off points
000279349 650_7 $$2Other$$adementia
000279349 650_7 $$2Other$$adiagnostic performance
000279349 650_7 $$2Other$$aintellectual disability
000279349 650_2 $$2MeSH$$aHumans
000279349 650_2 $$2MeSH$$aDown Syndrome: complications
000279349 650_2 $$2MeSH$$aIntellectual Disability: diagnosis
000279349 650_2 $$2MeSH$$aFemale
000279349 650_2 $$2MeSH$$aMale
000279349 650_2 $$2MeSH$$aNeuropsychological Tests: statistics & numerical data
000279349 650_2 $$2MeSH$$aCohort Studies
000279349 650_2 $$2MeSH$$aMiddle Aged
000279349 650_2 $$2MeSH$$aAged
000279349 650_2 $$2MeSH$$aDementia: diagnosis
000279349 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000279349 7001_ $$00009-0000-7117-2270$$aSandkühler, Katja$$b1
000279349 7001_ $$aVidela, Laura$$b2
000279349 7001_ $$aBenejam, Bessy$$b3
000279349 7001_ $$aCarmona-Iragui, Maria$$b4
000279349 7001_ $$aWlasich, Elisabeth$$b5
000279349 7001_ $$aKustermann, Julia$$b6
000279349 7001_ $$aBarroeta, Isabel$$b7
000279349 7001_ $$aVaqué-Alcázar, Lídia$$b8
000279349 7001_ $$aRodríguez-Baz, Íñigo$$b9
000279349 7001_ $$aBejanin, Alexandre$$b10
000279349 7001_ $$aFernández, Susana$$b11
000279349 7001_ $$aArranz, Javier$$b12
000279349 7001_ $$aArriola-Infante, Jose Enrique$$b13
000279349 7001_ $$aMaure-Blesa, Lucia$$b14
000279349 7001_ $$aJuan, Aida San$$b15
000279349 7001_ $$0P:(DE-2719)9001761$$aNübling, Georg$$b16$$udzne
000279349 7001_ $$0P:(DE-2719)9001249$$aWagemann, Olivia$$b17$$udzne
000279349 7001_ $$0P:(DE-2719)9002610$$aStockbauer, Anna$$b18$$udzne
000279349 7001_ $$aHassenstab, Jason$$b19
000279349 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b20$$udzne
000279349 7001_ $$aFortea, Juan$$b21
000279349 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.70307$$gVol. 21, no. 6, p. e70307$$n6$$pe70307$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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