TY  - JOUR
AU  - Soriano, Laura Del Hoyo
AU  - Sandkühler, Katja
AU  - Videla, Laura
AU  - Benejam, Bessy
AU  - Carmona-Iragui, Maria
AU  - Wlasich, Elisabeth
AU  - Kustermann, Julia
AU  - Barroeta, Isabel
AU  - Vaqué-Alcázar, Lídia
AU  - Rodríguez-Baz, Íñigo
AU  - Bejanin, Alexandre
AU  - Fernández, Susana
AU  - Arranz, Javier
AU  - Arriola-Infante, Jose Enrique
AU  - Maure-Blesa, Lucia
AU  - Juan, Aida San
AU  - Nübling, Georg
AU  - Wagemann, Olivia
AU  - Stockbauer, Anna
AU  - Hassenstab, Jason
AU  - Levin, Johannes
AU  - Fortea, Juan
TI  - Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis.
JO  - Alzheimer's and dementia
VL  - 21
IS  - 6
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00726
SP  - e70307
PY  - 2025
AB  - Cut-offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut-offs across sites.This dual-center cohort study included 673 adults with mild to moderate ID at different AD stages. We assessed ID classification discrepancies across sites and the impact on Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) cut-offs for AD dementia diagnosis derived from receiver operating characteristic analysis.Inter-rater agreement for ID level classification was 95
KW  - Humans
KW  - Down Syndrome: complications
KW  - Intellectual Disability: diagnosis
KW  - Female
KW  - Male
KW  - Neuropsychological Tests: statistics & numerical data
KW  - Cohort Studies
KW  - Middle Aged
KW  - Aged
KW  - Dementia: diagnosis
KW  - Alzheimer Disease: diagnosis
KW  - AD21 (Other)
KW  - Alzheimer's disease (Other)
KW  - Cambridge Cognitive Examination for Older Adults with Down Syndrome (Other)
KW  - Down Alzheimer Barcelona Neuroimaging Initiative (Other)
KW  - Down syndrome (Other)
KW  - Down syndrome–associated Alzheimer's disease (Other)
KW  - cut‐off points (Other)
KW  - dementia (Other)
KW  - diagnostic performance (Other)
KW  - intellectual disability (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40528393
C2  - pmc:PMC12173952
DO  - DOI:10.1002/alz.70307
UR  - https://pub.dzne.de/record/279349
ER  -