%0 Journal Article
%A Bernhardt, Alexander Maximilian
%A Rodríguez-Baz, Íñigo
%A Aldecoa, Iban
%A Arranz, Javier
%A Arriola-Infante, José Enrique
%A Maure-Blesa, Lucia
%A Carmona-Iragui, Maria
%A Longen, Sebastian
%A Trossbach, Svenja Verena
%A Giese, Armin
%A Matthias, Torsten
%A Benejam, Bessy
%A Videla, Laura
%A Del Hoyo Soriano, Laura
%A Barroeta, Isabel
%A Sanjuan, Aída
%A Fernández, Susana
%A Vaqué-Alcázar, Lídia
%A Rozalem Aranha, Mateus
%A Morcillo-Nieto, Alejandra O
%A Nübling, Georg
%A Wagemann, Olivia
%A Stockbauer, Anna
%A Tondo, Mireia
%A Bejanin, Alexandre
%A Lleó, Alberto
%A Alcolea, Daniel
%A Molina-Porcel, Laura
%A Fortea, Juan
%A Levin, Johannes
%T Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease.
%J Alzheimer's and dementia
%V 21
%N 6
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2025-00727
%P e70342
%D 2025
%X Alpha-synuclein (αSyn) seed amplification assay (SAA) enables in vivo study of αSyn but remains underexplored in Down syndrome-associated Alzheimer's disease (DSAD).We analyzed αSyn-SAA in cerebrospinal fluid (CSF) from 270 adults with Down syndrome, from the Down Alzheimer Barcelona Neuroimaging Initiative and from the AD21 cohort from the Department of Neurology at the University Hospital, Ludwig Maximilian University of Munich, Germany. Neuropathological examinations were conducted in 19 brain donors (five with ante mortem CSF). Participants were classified as asymptomatic or symptomatic (prodromal/dementia) Alzheimer's disease (AD). CSF Aβ1-42/1-40, CSF and plasma p-Tau181, and neurofilament light chain (NfL) levels were measured. Neuropathological evaluations assessed AD neuropathological changes and Lewy body pathology (LBP).ΑSyn-SAA was positive in 9.2
%K Humans
%K Alzheimer Disease: pathology
%K Alzheimer Disease: cerebrospinal fluid
%K alpha-Synuclein: cerebrospinal fluid
%K Down Syndrome: pathology
%K Down Syndrome: complications
%K Down Syndrome: cerebrospinal fluid
%K Female
%K Male
%K Middle Aged
%K Aged
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Brain: pathology
%K Biomarkers: cerebrospinal fluid
%K tau Proteins: cerebrospinal fluid
%K tau Proteins: blood
%K Adult
%K Neurofilament Proteins: cerebrospinal fluid
%K Neurofilament Proteins: blood
%K Alzheimer's disease (Other)
%K Down syndrome (Other)
%K Lewy body pathology (Other)
%K biomarker (Other)
%K neuropathology (Other)
%K seed amplification assay (Other)
%K α‐synuclein (Other)
%K alpha-Synuclein (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40528443
%2 pmc:PMC12173960
%R 10.1002/alz.70342
%U https://pub.dzne.de/record/279350