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000279367 1001_ $$0P:(DE-2719)2814291$$aTemp, Anna G M$$b0$$eFirst author
000279367 245__ $$aThe role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis.
000279367 260__ $$a[London]$$bSpringer Nature$$c2025
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000279367 520__ $$aRecent research has shown that cognitive reserve is associated with better cognitive abilities in ALS/MND, and that a slow brain ageing speed is associated with intact cognition in ALS. This study compares the effects of cognitive reserve and the predicted brain age difference (PAD) on the risk of being diagnosed with ALS, the risk of having cognitive or behavioral impairment, or even fronto-temporal dementia, and on disease duration.Our results indicated that neither PAD nor cognitive reserve was associated with an increased risk of ALS, but that higher PAD was associated with an increased risk of cognitive impairments and FTD, as well as a shortened disease duration. Higher cognitive reserve on the other hand was associated with a lower risk of cognitive impairment and a longer disease duration.Brain age as a proxy of brain reserve influences disease progression and presentation more strongly than cognitive reserve.
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000279367 650_2 $$2MeSH$$aHumans
000279367 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: physiopathology
000279367 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: psychology
000279367 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: pathology
000279367 650_2 $$2MeSH$$aCognitive Reserve: physiology
000279367 650_2 $$2MeSH$$aDisease Progression
000279367 650_2 $$2MeSH$$aMale
000279367 650_2 $$2MeSH$$aFemale
000279367 650_2 $$2MeSH$$aMiddle Aged
000279367 650_2 $$2MeSH$$aBrain: physiopathology
000279367 650_2 $$2MeSH$$aBrain: pathology
000279367 650_2 $$2MeSH$$aAged
000279367 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000279367 650_2 $$2MeSH$$aCognition
000279367 650_2 $$2MeSH$$aFrontotemporal Dementia: physiopathology
000279367 7001_ $$aTarakdjian, Gaël Nils$$b1
000279367 7001_ $$0P:(DE-2719)9000419$$aKasper, Elisabeth$$b2$$udzne
000279367 7001_ $$0P:(DE-2719)2810317$$aMachts, Judith$$b3$$udzne
000279367 7001_ $$aKaufmann, Jörn$$b4
000279367 7001_ $$0P:(DE-2719)2000035$$aVielhaber, Stefan$$b5$$udzne
000279367 7001_ $$0P:(DE-2719)2380559$$aPrudlo, Johannes$$b6$$udzne
000279367 7001_ $$aCole, James H$$b7
000279367 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b8$$udzne
000279367 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b9$$udzne
000279367 7001_ $$0P:(DE-2719)2811732$$aHermann, Andreas$$b10$$eLast author$$udzne
000279367 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-97509-y$$gVol. 15, no. 1, p. 20232$$n1$$p20232$$tScientific reports$$v15$$x2045-2322$$y2025
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