TY  - JOUR
AU  - Temp, Anna G M
AU  - Tarakdjian, Gaël Nils
AU  - Kasper, Elisabeth
AU  - Machts, Judith
AU  - Kaufmann, Jörn
AU  - Vielhaber, Stefan
AU  - Prudlo, Johannes
AU  - Cole, James H
AU  - Dyrba, Martin
AU  - Teipel, Stefan
AU  - Hermann, Andreas
TI  - The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis.
JO  - Scientific reports
VL  - 15
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00744
SP  - 20232
PY  - 2025
AB  - Recent research has shown that cognitive reserve is associated with better cognitive abilities in ALS/MND, and that a slow brain ageing speed is associated with intact cognition in ALS. This study compares the effects of cognitive reserve and the predicted brain age difference (PAD) on the risk of being diagnosed with ALS, the risk of having cognitive or behavioral impairment, or even fronto-temporal dementia, and on disease duration.Our results indicated that neither PAD nor cognitive reserve was associated with an increased risk of ALS, but that higher PAD was associated with an increased risk of cognitive impairments and FTD, as well as a shortened disease duration. Higher cognitive reserve on the other hand was associated with a lower risk of cognitive impairment and a longer disease duration.Brain age as a proxy of brain reserve influences disease progression and presentation more strongly than cognitive reserve.
KW  - Humans
KW  - Amyotrophic Lateral Sclerosis: physiopathology
KW  - Amyotrophic Lateral Sclerosis: psychology
KW  - Amyotrophic Lateral Sclerosis: pathology
KW  - Cognitive Reserve: physiology
KW  - Disease Progression
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Brain: physiopathology
KW  - Brain: pathology
KW  - Aged
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognition
KW  - Frontotemporal Dementia: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:40542104
C2  - pmc:PMC12181229
DO  - DOI:10.1038/s41598-025-97509-y
UR  - https://pub.dzne.de/record/279367
ER  -