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@ARTICLE{Temp:279367,
      author       = {Temp, Anna G M and Tarakdjian, Gaël Nils and Kasper,
                      Elisabeth and Machts, Judith and Kaufmann, Jörn and
                      Vielhaber, Stefan and Prudlo, Johannes and Cole, James H and
                      Dyrba, Martin and Teipel, Stefan and Hermann, Andreas},
      title        = {{T}he role of cognitive and brain reserve in the clinical
                      presentation and progression of amyotrophic lateral
                      sclerosis.},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00744},
      pages        = {20232},
      year         = {2025},
      abstract     = {Recent research has shown that cognitive reserve is
                      associated with better cognitive abilities in ALS/MND, and
                      that a slow brain ageing speed is associated with intact
                      cognition in ALS. This study compares the effects of
                      cognitive reserve and the predicted brain age difference
                      (PAD) on the risk of being diagnosed with ALS, the risk of
                      having cognitive or behavioral impairment, or even
                      fronto-temporal dementia, and on disease duration.Our
                      results indicated that neither PAD nor cognitive reserve was
                      associated with an increased risk of ALS, but that higher
                      PAD was associated with an increased risk of cognitive
                      impairments and FTD, as well as a shortened disease
                      duration. Higher cognitive reserve on the other hand was
                      associated with a lower risk of cognitive impairment and a
                      longer disease duration.Brain age as a proxy of brain
                      reserve influences disease progression and presentation more
                      strongly than cognitive reserve.},
      keywords     = {Humans / Amyotrophic Lateral Sclerosis: physiopathology /
                      Amyotrophic Lateral Sclerosis: psychology / Amyotrophic
                      Lateral Sclerosis: pathology / Cognitive Reserve: physiology
                      / Disease Progression / Male / Female / Middle Aged / Brain:
                      physiopathology / Brain: pathology / Aged / Cognitive
                      Dysfunction: physiopathology / Cognition / Frontotemporal
                      Dementia: physiopathology},
      cin          = {AG Hermann / AG Teipel / AG Düzel},
      ddc          = {600},
      cid          = {I:(DE-2719)1511100 / I:(DE-2719)1510100 /
                      I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40542104},
      pmc          = {pmc:PMC12181229},
      doi          = {10.1038/s41598-025-97509-y},
      url          = {https://pub.dzne.de/record/279367},
}