%0 Journal Article
%A Barlescu, Lavinia
%A Höglinger, Günter U
%A Volkmann, Heiko
%A Ludolph, Albert C
%A Del Tredici, Kelly
%A Braak, Heiko
%A Müller, Hans-Peter
%A Kassubek, Jan
%T Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy.
%J Frontiers in aging neuroscience
%V 17
%@ 1663-4365
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2025-00745
%P 1569302
%D 2025
%X A neuropathological cerebral staging concept for progressive supranuclear palsy (PSP) has been proposed that tau inclusions in PSP may progress in a sequential regional pattern. The objective was to develop a hypothesis-guided region/tract of interest-based (ROI/TOI) approach to use diffusion tensor imaging (DTI) targeted to analyze in vivo the regions that are prone to be involved at each neuropathological stage of PSP.Two data cohorts were analyzed: cohort A of 78 PSP patients [55 Richardson's syndrome (PSP-RS) and 23 PSP with predominant parkinsonism (PSP-P)] and 63 controls, recorded at 3.0T at multiple sites, and a single-site cohort B constituted by 1.5T data of 66 PSP patients (46 PSP-RS and 20 PSP-P) and 44 controls. In cohort A, 21 PSP patients (13 PSP-RS and 8 PSP-P) and 17 controls obtained a follow-up scan after 17 months. Whole brain-based spatial statistics (WBSS) was used to identify the alterations in PSP patients vs. controls. The combined ROI- and TOI-based approach targeted structures that are prone to be involved during the course of PSP.WBSS demonstrated alterations predominantly in brainstem/midbrain, basal ganglia, and frontal lobe, more pronounced in the longitudinal data. Statistical analyses of the ROIs/TOIs showed a sequential pattern of structures that were assigned to previously defined neuropathological steps.The combined ROI- and TOI-based DTI approach was able to map the disease stages of PSP in vivo cross-sectionally and longitudinally, lending support to DTI as a technical marker for imaging disease progression according to PSP stages. This approach might be useful as a tool for stratification of PSP patients MRI with respect to its proposed neuropathological progression in future longitudinal and autopsy-controlled studies.
%K diffusion tensor imaging (DTI) (Other)
%K neuropathology (Other)
%K progressive supranuclear palsy (Other)
%K sequential pattern (Other)
%K tau protein (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40547840
%2 pmc:PMC12179216
%R 10.3389/fnagi.2025.1569302
%U https://pub.dzne.de/record/279368