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000279368 1001_ $$0P:(DE-2719)9002368$$aBarlescu, Lavinia$$b0$$udzne
000279368 245__ $$aDiffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy.
000279368 260__ $$aLausanne$$bFrontiers Research Foundation$$c2025
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000279368 520__ $$aA neuropathological cerebral staging concept for progressive supranuclear palsy (PSP) has been proposed that tau inclusions in PSP may progress in a sequential regional pattern. The objective was to develop a hypothesis-guided region/tract of interest-based (ROI/TOI) approach to use diffusion tensor imaging (DTI) targeted to analyze in vivo the regions that are prone to be involved at each neuropathological stage of PSP.Two data cohorts were analyzed: cohort A of 78 PSP patients [55 Richardson's syndrome (PSP-RS) and 23 PSP with predominant parkinsonism (PSP-P)] and 63 controls, recorded at 3.0T at multiple sites, and a single-site cohort B constituted by 1.5T data of 66 PSP patients (46 PSP-RS and 20 PSP-P) and 44 controls. In cohort A, 21 PSP patients (13 PSP-RS and 8 PSP-P) and 17 controls obtained a follow-up scan after 17 months. Whole brain-based spatial statistics (WBSS) was used to identify the alterations in PSP patients vs. controls. The combined ROI- and TOI-based approach targeted structures that are prone to be involved during the course of PSP.WBSS demonstrated alterations predominantly in brainstem/midbrain, basal ganglia, and frontal lobe, more pronounced in the longitudinal data. Statistical analyses of the ROIs/TOIs showed a sequential pattern of structures that were assigned to previously defined neuropathological steps.The combined ROI- and TOI-based DTI approach was able to map the disease stages of PSP in vivo cross-sectionally and longitudinally, lending support to DTI as a technical marker for imaging disease progression according to PSP stages. This approach might be useful as a tool for stratification of PSP patients MRI with respect to its proposed neuropathological progression in future longitudinal and autopsy-controlled studies.
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000279368 650_7 $$2Other$$adiffusion tensor imaging (DTI)
000279368 650_7 $$2Other$$aneuropathology
000279368 650_7 $$2Other$$aprogressive supranuclear palsy
000279368 650_7 $$2Other$$asequential pattern
000279368 650_7 $$2Other$$atau protein
000279368 693__ $$0EXP:(DE-2719)DESCRIBE-PSP-20160101$$5EXP:(DE-2719)DESCRIBE-PSP-20160101$$eDZNE Clinical Registry Study of Neurodegenerative Diseases in Patients with Progressive Supranuclear Paresis (PSP)$$x0
000279368 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter U$$b1$$udzne
000279368 7001_ $$aVolkmann, Heiko$$b2
000279368 7001_ $$0P:(DE-2719)2812633$$aLudolph, Albert C$$b3$$udzne
000279368 7001_ $$aDel Tredici, Kelly$$b4
000279368 7001_ $$aBraak, Heiko$$b5
000279368 7001_ $$aMüller, Hans-Peter$$b6
000279368 7001_ $$0P:(DE-2719)9001967$$aKassubek, Jan$$b7$$udzne
000279368 7001_ $$aGroup, DESCRIBE-PSP Study$$b8$$eCollaboration Author
000279368 7001_ $$0P:(DE-2719)2812107$$aBrandt, Moritz$$b9$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b10$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b11$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2814178$$aFalkenburger, Björn$$b12$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b13$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b14$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b15$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b16$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)9001160$$aKatzdobler, Sabrina$$b17$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b18$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)9002382$$aKimmich, Okka$$b19$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b20$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b21$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b22$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2380559$$aPrudlo, Johannes$$b23$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)9002878$$aSchneider, Luisa-Sophie$$b24$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b25$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b26$$eContributor
000279368 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b27$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b28$$eContributor$$udzne
000279368 7001_ $$0P:(DE-2719)2814101$$aWilke, Carlo$$b29$$eContributor$$udzne
000279368 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2025.1569302$$gVol. 17, p. 1569302$$p1569302$$tFrontiers in aging neuroscience$$v17$$x1663-4365$$y2025
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