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@ARTICLE{Barlescu:279368,
      author       = {Barlescu, Lavinia and Höglinger, Günter U and Volkmann,
                      Heiko and Ludolph, Albert C and Del Tredici, Kelly and
                      Braak, Heiko and Müller, Hans-Peter and Kassubek, Jan},
      collaboration = {Group, DESCRIBE-PSP Study},
      othercontributors = {Brandt, Moritz and Bürger, Katharina and Düzel, Emrah and
                          Falkenburger, Björn and Flöel, Agnes and Glanz, Wenzel and
                          Höglinger, Günter and Janowitz, Daniel and Katzdobler,
                          Sabrina and Kilimann, Ingo and Kimmich, Okka and Levin,
                          Johannes and Peters, Oliver and Priller, Josef and Prudlo,
                          Johannes and Schneider, Luisa-Sophie and Spottke, Annika and
                          Spruth, Eike Jakob and Synofzik, Matthis and Teipel, Stefan
                          and Wilke, Carlo},
      title        = {{D}iffusion tensor imaging of sequential neuropathological
                      patterns in progressive supranuclear palsy.},
      journal      = {Frontiers in aging neuroscience},
      volume       = {17},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00745},
      pages        = {1569302},
      year         = {2025},
      abstract     = {A neuropathological cerebral staging concept for
                      progressive supranuclear palsy (PSP) has been proposed that
                      tau inclusions in PSP may progress in a sequential regional
                      pattern. The objective was to develop a hypothesis-guided
                      region/tract of interest-based (ROI/TOI) approach to use
                      diffusion tensor imaging (DTI) targeted to analyze in vivo
                      the regions that are prone to be involved at each
                      neuropathological stage of PSP.Two data cohorts were
                      analyzed: cohort A of 78 PSP patients [55 Richardson's
                      syndrome (PSP-RS) and 23 PSP with predominant parkinsonism
                      (PSP-P)] and 63 controls, recorded at 3.0T at multiple
                      sites, and a single-site cohort B constituted by 1.5T data
                      of 66 PSP patients (46 PSP-RS and 20 PSP-P) and 44 controls.
                      In cohort A, 21 PSP patients (13 PSP-RS and 8 PSP-P) and 17
                      controls obtained a follow-up scan after 17 months. Whole
                      brain-based spatial statistics (WBSS) was used to identify
                      the alterations in PSP patients vs. controls. The combined
                      ROI- and TOI-based approach targeted structures that are
                      prone to be involved during the course of PSP.WBSS
                      demonstrated alterations predominantly in
                      brainstem/midbrain, basal ganglia, and frontal lobe, more
                      pronounced in the longitudinal data. Statistical analyses of
                      the ROIs/TOIs showed a sequential pattern of structures that
                      were assigned to previously defined neuropathological
                      steps.The combined ROI- and TOI-based DTI approach was able
                      to map the disease stages of PSP in vivo cross-sectionally
                      and longitudinally, lending support to DTI as a technical
                      marker for imaging disease progression according to PSP
                      stages. This approach might be useful as a tool for
                      stratification of PSP patients MRI with respect to its
                      proposed neuropathological progression in future
                      longitudinal and autopsy-controlled studies.},
      keywords     = {diffusion tensor imaging (DTI) (Other) / neuropathology
                      (Other) / progressive supranuclear palsy (Other) /
                      sequential pattern (Other) / tau protein (Other)},
      cin          = {Clinical Research (Munich) / Clinical Study Center (Ulm)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DESCRIBE-PSP-20160101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40547840},
      pmc          = {pmc:PMC12179216},
      doi          = {10.3389/fnagi.2025.1569302},
      url          = {https://pub.dzne.de/record/279368},
}