TY  - JOUR
AU  - Gisa, Verena
AU  - Islam, Md Rezaul
AU  - Lbik, Dawid
AU  - Hofmann, Raoul Maximilian
AU  - Pena, Tonatiuh
AU  - Krüger, Dennis Manfred
AU  - Burkhardt, Susanne
AU  - Schütz, Anna-Lena
AU  - Sananbenesi, Farahnaz
AU  - Toischer, Karl
AU  - Fischer, Andre
TI  - Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure.
JO  - Non-Coding RNA
VL  - 11
IS  - 3
SN  - 2311-553X
CY  - Basel
PB  - MDPI
M1  - DZNE-2025-00752
SP  - 45
PY  - 2025
AB  - Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet the underlying molecular mechanisms remain poorly understood. This study aims to investigate the role of microRNA (miRNA) networks in hippocampus-dependent memory recovery in a mouse model of HF. Methods: CaMKIIδC transgenic (TG) mice, a model for HF, were used to assess hippocampal function at 3 and 6 months of age. Memory performance was evaluated using hippocampus-dependent behavioral tasks. Small RNA sequencing was performed to analyze hippocampal miRNA expression profiles across both time points. Bioinformatic analyses identified miRNAs that potentially regulate genes previously implicated in HF-induced cognitive impairment. Results: We have previously shown that at 3 months of age, CaMKIIδC TG mice exhibited significant memory deficits associated with dysregulated hippocampal gene expression. In this study, we showed that these impairments, memory impairment and hippocampal gene expression, were no longer detectable at 6 months, despite persistent cardiac dysfunction. However, small RNA sequencing revealed a dynamic shift in hippocampal miRNA expression, identifying 27 miRNAs as 'compensatory miRs' that targeted 73
KW  - Alzheimer (Other)
KW  - MicroRNA (Other)
KW  - cognitive impairment (Other)
KW  - heart failure (Other)
KW  - hippocampal function (Other)
KW  - memory recovery (Other)
KW  - transcriptional homeostasis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40559623
C2  - pmc:PMC12196295
DO  - DOI:10.3390/ncrna11030045
UR  - https://pub.dzne.de/record/279375
ER  -