TY  - JOUR
AU  - Porsche, Sonja
AU  - Klietz, Martin
AU  - Greten, Stephan
AU  - Piot, Ines
AU  - Jensen, Ida
AU  - Wegner, Florian
AU  - Ye, Lan
AU  - Krey, Lea
AU  - Höllerhage, Matthias
AU  - Pötter-Nerger, Monika
AU  - Zeitzschel, Molly
AU  - Hagena, Keno
AU  - Kassubek, Jan
AU  - Süß, Patrick
AU  - Winkler, Jürgen
AU  - Berg, Daniela
AU  - Paschen, Steffen
AU  - Tönges, Lars
AU  - Gruber, Doreen
AU  - Gandor, Florin
AU  - Jost, Wolfgang H
AU  - Kühn, Andrea A
AU  - Claus, Inga
AU  - Warnecke, Tobias
AU  - Pedrosa, David J
AU  - Eggers, Carsten
AU  - Trenkwalder, Claudia
AU  - Classen, Joseph
AU  - Schwarz, Johannes
AU  - Schnitzler, Alfons
AU  - Krause, Patricia
AU  - Schneider, Anja
AU  - Brandt, Moritz
AU  - Falkenburger, Björn
AU  - Zerr, Inga
AU  - Bähr, Mathias
AU  - Weidinger, Endy
AU  - Levin, Johannes
AU  - Katzdobler, Sabrina
AU  - Düzel, Emrah
AU  - Glanz, Wenzel
AU  - Teipel, Stefan
AU  - Kilimann, Ingo
AU  - Prudlo, Johannes
AU  - Gasser, Thomas
AU  - Brockmann, Kathrin
AU  - Spottke, Annika
AU  - Esser, Anna
AU  - Petzold, Gabor C
AU  - Respondek, Gesine
AU  - Höglinger, Günter U
TI  - A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.
JO  - Movement disorders clinical practice
VL  - 12
IS  - 6
SN  - 2330-1619
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2025-00755
SP  - 764 - 774
PY  - 2025
AB  - Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing.To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP.The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed.Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = -0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022).The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.
KW  - Humans
KW  - Supranuclear Palsy, Progressive: complications
KW  - Supranuclear Palsy, Progressive: diagnosis
KW  - Supranuclear Palsy, Progressive: psychology
KW  - Male
KW  - Female
KW  - Aged
KW  - Neuropsychological Tests
KW  - Cross-Sectional Studies
KW  - Middle Aged
KW  - Aged, 80 and over
KW  - Longitudinal Studies
KW  - Severity of Illness Index
KW  - 4‐repeat tauopathies (Other)
KW  - Progressive Supranuclear Palsy (Other)
KW  - cognition (Other)
KW  - depression (Other)
KW  - quality of life (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39868903
C2  - pmc:PMC12187960
DO  - DOI:10.1002/mdc3.14348
UR  - https://pub.dzne.de/record/279378
ER  -