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@ARTICLE{Porsche:279378,
      author       = {Porsche, Sonja and Klietz, Martin and Greten, Stephan and
                      Piot, Ines and Jensen, Ida and Wegner, Florian and Ye, Lan
                      and Krey, Lea and Höllerhage, Matthias and Pötter-Nerger,
                      Monika and Zeitzschel, Molly and Hagena, Keno and Kassubek,
                      Jan and Süß, Patrick and Winkler, Jürgen and Berg,
                      Daniela and Paschen, Steffen and Tönges, Lars and Gruber,
                      Doreen and Gandor, Florin and Jost, Wolfgang H and Kühn,
                      Andrea A and Claus, Inga and Warnecke, Tobias and Pedrosa,
                      David J and Eggers, Carsten and Trenkwalder, Claudia and
                      Classen, Joseph and Schwarz, Johannes and Schnitzler, Alfons
                      and Krause, Patricia and Schneider, Anja and Brandt, Moritz
                      and Falkenburger, Björn and Zerr, Inga and Bähr, Mathias
                      and Weidinger, Endy and Levin, Johannes and Katzdobler,
                      Sabrina and Düzel, Emrah and Glanz, Wenzel and Teipel,
                      Stefan and Kilimann, Ingo and Prudlo, Johannes and Gasser,
                      Thomas and Brockmann, Kathrin and Spottke, Annika and Esser,
                      Anna and Petzold, Gabor C and Respondek, Gesine and
                      Höglinger, Günter U},
      title        = {{A} {S}hort {C}ognitive and {N}europsychiatric {A}ssessment
                      {S}cale for {P}rogressive {S}upranuclear {P}alsy.},
      journal      = {Movement disorders clinical practice},
      volume       = {12},
      number       = {6},
      issn         = {2330-1619},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00755},
      pages        = {764 - 774},
      year         = {2025},
      abstract     = {Patients with Progressive Supranuclear Palsy (PSP) suffer
                      from several neuropsychological impairments. These mainly
                      affect the frontal lobe and subcortical brain structures.
                      However, a scale for the assessment of cognitive and
                      neuropsychiatric disability in PSP is still missing.To
                      create and validate a new scale for cognitive and
                      neuropsychiatric impairment in PSP.The Short Cognitive and
                      Neuropsychiatric (ShoCo) scale was developed containing five
                      items (bradyphrenia, apathy, aphasia, dysexecution and
                      disinhibition). Each item can be categorized into 0 = no
                      deficit, 1 = mild deficit, 2 = moderate deficit and 3 =
                      severe deficit. The total score includes 15 points, 0
                      meaning no deficit and 15 severe deficits. Cross-sectional
                      and longitudinal data from 201 baseline and 71 follow up
                      patients were analyzed.Baseline ShoCo scale results were 5.9
                      ± 2.9. No significant differences between patients with
                      Richardson syndrome (PSP-RS) and variants (vPSP) could be
                      detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n
                      = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed
                      good correlation with established scores (eg, Montreal
                      cognitive assessment r = -0.535, P = 0.001). The ShoCo scale
                      showed significant annualized change within the PSP-RS
                      patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1,
                      annualized diff. 1.0 ± 3.1, n = 57, P = 0.022).The ShoCo
                      scale seems a promising and valid tool to measure specific
                      neuropsychological disabilities of PSP patients in clinical
                      routine and research.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: complications /
                      Supranuclear Palsy, Progressive: diagnosis / Supranuclear
                      Palsy, Progressive: psychology / Male / Female / Aged /
                      Neuropsychological Tests / Cross-Sectional Studies / Middle
                      Aged / Aged, 80 and over / Longitudinal Studies / Severity
                      of Illness Index / 4‐repeat tauopathies (Other) /
                      Progressive Supranuclear Palsy (Other) / cognition (Other) /
                      depression (Other) / quality of life (Other)},
      cin          = {Clinical Study Center (Ulm) / AG Kühn / Clinical Research
                      (Munich) / AG Levin / AG Schneider / AG Falkenburger / AG
                      Zerr / Clinical Dementia Research (Göttingen) / AG Düzel /
                      AG Teipel / AG Gasser / AG Spottke / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077 / I:(DE-2719)5000008 /
                      I:(DE-2719)1111015 / I:(DE-2719)1111016 / I:(DE-2719)1011305
                      / I:(DE-2719)1710012 / I:(DE-2719)1440011-1 /
                      I:(DE-2719)1440015 / I:(DE-2719)5000006 / I:(DE-2719)1510100
                      / I:(DE-2719)1210000 / I:(DE-2719)1011103 /
                      I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39868903},
      pmc          = {pmc:PMC12187960},
      doi          = {10.1002/mdc3.14348},
      url          = {https://pub.dzne.de/record/279378},
}