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001     279378
005     20250828101646.0
024 7 _ |a 10.1002/mdc3.14348
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024 7 _ |a pmc:PMC12187960
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037 _ _ |a DZNE-2025-00755
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Porsche, Sonja
|0 0009-0009-4542-3000
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245 _ _ |a A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.
260 _ _ |a New York, NY
|c 2025
|b Wiley
336 7 _ |a article
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336 7 _ |a ARTICLE
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520 _ _ |a Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing.To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP.The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed.Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = -0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022).The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.
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650 _ 7 |a 4‐repeat tauopathies
|2 Other
650 _ 7 |a Progressive Supranuclear Palsy
|2 Other
650 _ 7 |a cognition
|2 Other
650 _ 7 |a depression
|2 Other
650 _ 7 |a quality of life
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: complications
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: diagnosis
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: psychology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Severity of Illness Index
|2 MeSH
700 1 _ |a Klietz, Martin
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700 1 _ |a Brockmann, Kathrin
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700 1 _ |a Respondek, Gesine
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700 1 _ |a Höglinger, Günter U
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773 _ _ |a 10.1002/mdc3.14348
|g Vol. 12, no. 6, p. 764 - 774
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