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000279427 037__ $$aDZNE-2025-00758
000279427 041__ $$aEnglish
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000279427 1001_ $$aStürmer, Marian$$b0
000279427 245__ $$aLong-term alteration of heart rate variability following childhood maltreatment: Results of a general population study.
000279427 260__ $$aCambridge$$bCambridge University Press$$c2025
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000279427 520__ $$aChildhood maltreatment (CM) is a risk factor for mental and physical health problems in adulthood, potentially mediated by long-term autonomic nervous system (ANS) dysregulation. To explore this link, the association between CM and vagal-sensitive heart rate variability (HRV) metrics in adults was examined, accounting for biopsychosocial factors.Data from 4,420 participants in the Study of Health in Pomerania were analyzed, with CM assessed using the Childhood Trauma Questionnaire. HRV was derived from 10-second electrocardiograms and 5-minute pre-sleep polysomnographic recordings. Post hoc analyses examined abuse and neglect.CM was associated with reduced HRV (logRMSSD: β = -0.20 [95%-CI: -0.28, -0.12], p = 1.2e-06), driven by neglect (β = -0.27 [-0.35, -0.18], p = 1.9e-09) rather than abuse (β = 0.01 [-0.12, 0.14], p = 1). Adjustments for age, sex, and medication attenuated these effects, which remained robust after additionally controlling for socioeconomic, lifestyle, body mass index, and depressive symptoms (fully adjusted model: CM β = -0.08 [-0.15, -0.001], p = .047; neglect β = -0.11 [-0.19, -0.03], p = .009; abuse β = -0.08 [-0.20, -0.04], p = .174). Age-related differences were found, with reduced HRV in both young and older participants but not in middle-aged participants (fully adjusted: F(2,743) = 6.75, p = .001).This study highlights long-term ANS dysregulation following CM, particularly neglect, indicated by altered vagal-sensitive HRV metrics. Although small in magnitude, the effect on the ANS was independent of adult biopsychosocial factors. This long-term dysregulation may contribute to an increased risk of adverse health outcomes in adulthood.
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000279427 650_7 $$2Other$$aCTQ
000279427 650_7 $$2Other$$aECG
000279427 650_7 $$2Other$$aRMSSD
000279427 650_7 $$2Other$$achildhood maltreatment
000279427 650_7 $$2Other$$aheart rate variability
000279427 650_2 $$2MeSH$$aHumans
000279427 650_2 $$2MeSH$$aMale
000279427 650_2 $$2MeSH$$aHeart Rate: physiology
000279427 650_2 $$2MeSH$$aFemale
000279427 650_2 $$2MeSH$$aMiddle Aged
000279427 650_2 $$2MeSH$$aAdult
000279427 650_2 $$2MeSH$$aAutonomic Nervous System: physiopathology
000279427 650_2 $$2MeSH$$aAdult Survivors of Child Abuse: statistics & numerical data
000279427 650_2 $$2MeSH$$aElectrocardiography
000279427 650_2 $$2MeSH$$aAged
000279427 650_2 $$2MeSH$$aPolysomnography
000279427 7001_ $$00000-0003-2287-7914$$aKlinger-König, Johanna$$b1
000279427 7001_ $$00000-0002-4593-2026$$aVollmer, Marcus$$b2
000279427 7001_ $$0P:(DE-2719)9002604$$aWeihs, Antoine$$b3
000279427 7001_ $$00000-0001-5087-5970$$aFrenzel, Stefan$$b4
000279427 7001_ $$00000-0001-7471-475X$$aDörr, Marcus$$b5
000279427 7001_ $$00000-0002-2359-2294$$aKaderali, Lars$$b6
000279427 7001_ $$aFelix, Stephan B$$b7
000279427 7001_ $$aStubbe, Beate$$b8
000279427 7001_ $$00000-0002-6746-9925$$aEwert, Ralf$$b9
000279427 7001_ $$aVölzke, Henry$$b10
000279427 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans J$$b11$$udzne
000279427 7001_ $$00000-0002-7222-2249$$aKrause, Elischa$$b12
000279427 773__ $$0PERI:(DE-600)2005377-0$$a10.1192/j.eurpsy.2025.10040$$gVol. 68, no. 1, p. e86$$n1$$pe86$$tEuropean psychiatry$$v68$$x0924-9338$$y2025
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