Home > Publications Database > Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation. > print

001     279437
005     20250720001546.0
024 7 _ |a 10.1038/s41467-025-61018-3
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037 _ _ |a DZNE-2025-00768
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082 _ _ |a 500
100 1 _ |a Martínez-Rojas, Beatriz
|0 0000-0001-7513-1396
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245 _ _ |a Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation.
260 _ _ |a [London]
|c 2025
|b Springer Nature
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520 _ _ |a After spinal cord injury (SCI), cyclic adenosine monophosphate (cAMP) levels drop in the spinal cord, cortex and brainstem, unlike in regenerating peripheral neurons. To address SCI recovery, we expressed photoactivatable adenylate cyclase (bPAC) in corticospinal neurons of female rats with dorsal hemisection for on-demand cAMP inductions. bPAC stimulation restored passive and firing properties of corticospinal neurons, promoted early and sustained locomotor recovery and increased corticospinal tract plasticity. Additionally, bPAC enhanced sparing of lumbar-projecting brainstem neurons after SCI, accompanied by activation of cAMP signaling in the raphe-reticular formation and increased excitatory/inhibitory neurotransmitter balance. Accordingly, augmented density of serotonergic tracts was found caudal to the injury in bPAC rats, correlating with enhanced functional performance. Serotonergic implication in motor recovery was further evidenced by selective depletion, resulting in the abrogation of bPAC-mediated recovery. Overall, our findings underscore that cAMP induction in corticospinal neurons enhances locomotion after SCI, through a cortical rerouting pathway via the serotonergic descending tract.
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650 _ 7 |a Cyclic AMP
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650 _ 7 |a Adenylyl Cyclases
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: physiopathology
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: metabolism
|2 MeSH
650 _ 2 |a Spinal Cord Injuries: therapy
|2 MeSH
650 _ 2 |a Cyclic AMP: metabolism
|2 MeSH
650 _ 2 |a Pyramidal Tracts: metabolism
|2 MeSH
650 _ 2 |a Pyramidal Tracts: physiopathology
|2 MeSH
650 _ 2 |a Optogenetics: methods
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Recovery of Function: physiology
|2 MeSH
650 _ 2 |a Adenylyl Cyclases: metabolism
|2 MeSH
650 _ 2 |a Adenylyl Cyclases: genetics
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Rats, Sprague-Dawley
|2 MeSH
650 _ 2 |a Locomotion: physiology
|2 MeSH
650 _ 2 |a Serotonergic Neurons: metabolism
|2 MeSH
650 _ 2 |a Neuronal Plasticity
|2 MeSH
700 1 _ |a Martín-Pérez, Samuel
|0 0009-0007-7062-8695
|b 1
700 1 _ |a Giraldo, Esther
|0 0000-0001-5488-3011
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700 1 _ |a Lopez-Mocholi, Eric
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700 1 _ |a Alastrue, Ana
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700 1 _ |a Andrade-Talavera, Yuniesky
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700 1 _ |a Prius-Mengual, Jose
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700 1 _ |a Paniagua, Guillem
|0 0000-0003-2292-5330
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700 1 _ |a Pedraza, Maria
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700 1 _ |a Hingorani, Sonia
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700 1 _ |a Rost, Benjamin R
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700 1 _ |a Schmitz, Dietmar
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700 1 _ |a Llansola, Marta
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700 1 _ |a Felipo, Vicente
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700 1 _ |a Rodríguez-Moreno, Antonio
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700 1 _ |a Moreno-Manzano, Victoria
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773 _ _ |a 10.1038/s41467-025-61018-3
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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