001     279473
005     20250710100950.0
024 7 _ |a 10.5061/DRYAD.XGXD254RB
|2 doi
024 7 _ |a 10.5061/dryad.xgxd254rb
|2 doi
037 _ _ |a DZNE-2025-00800
041 _ _ |a English
100 1 _ |a Kempermann, Gerd
|0 P:(DE-2719)2000011
|b 0
245 _ _ |a Dataset: Individual choices shape divergent brains and behaviors
260 _ _ |c 2025
|b Dryad
336 7 _ |a MISC
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336 7 _ |a Dataset
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|s 1752049465_18284
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336 7 _ |a Chart or Table
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336 7 _ |a Dataset
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336 7 _ |a DATA_SET
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336 7 _ |a ResearchData
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520 _ _ |a Individual choices shape life course trajectories of brain structure and function beyond genes and environment. We hypothesized that individual task engagement in response to a learning program results in individualized learning biographies and connectomics. Genetically identical female mice living in one large shared enclosure freely engaged in self-paced, automatically administered and monitored learning tasks. We discovered growing and increasingly stable inter-individual differences in learning trajectories. Adult hippocampal neurogenesis and connectivity as assessed by a high-density multi-electrode array positively correlated with the variation in exploration and learning efficiency. During some tasks, divergence transiently collapsed, highlighting the sustained significance of context for individualization. Thus, equal environments and equal genes do not result in equal learning biographies because life confronts individuals with choices that lead to divergent paths.
536 _ _ |a 351 - Brain Function (POF4-351)
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536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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588 _ _ |a Dataset connected to DataCite
650 _ 7 |a Individuality
|2 Other
650 _ 7 |a Behavior
|2 Other
650 _ 7 |a Learning
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650 _ 7 |a mouse
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650 _ 7 |a tracking
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650 _ 7 |a Intellicage
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650 _ 7 |a FOS: Biological sciences
|2 Other
700 1 _ |a Barde, Warsha
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700 1 _ |a Renner, Jonas
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700 1 _ |a Emery, Brett
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700 1 _ |a Khanzada, Shakrukh
|0 P:(DE-HGF)0
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700 1 _ |a Hu, Xin
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700 1 _ |a Garthe, Alexander
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700 1 _ |a Rünker, Annette
|0 P:(DE-2719)2810792
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700 1 _ |a Amin, Hayder
|0 P:(DE-2719)2812628
|b 8
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773 _ _ |a 10.5061/dryad.xgxd254rb
909 C O |o oai:pub.dzne.de:279473
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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913 1 _ |a DE-HGF
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914 1 _ |y 2025
920 1 _ |0 I:(DE-2719)1710010
|k AG Amin
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920 1 _ |0 I:(DE-2719)1710001
|k AG Kempermann
|l Adult Neurogenesis
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920 1 _ |0 I:(DE-2719)1740001
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980 _ _ |a dataset
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1710010
980 _ _ |a I:(DE-2719)1710001
980 _ _ |a I:(DE-2719)1740001
980 _ _ |a UNRESTRICTED


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