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@MISC{Mller:279490,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {P}lasma proteomics of mice treated with {BACE}
                      inhibitors},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-00817},
      year         = {2024},
      abstract     = {The Beta-secretase BACE1 is a central drug target for
                      Alzheimer’s disease. Clinically tested, BACE1-directed
                      inhibitors also block the homologous protease BACE2. Yet,
                      little is known about physiological BACE2 substrates and
                      functions in vivo. To discover potential BAC2 substrates in
                      plasma, mice were treated with a non-specific BACE inhibitor
                      (Cpd89) and a BACE1 preferring inhibitor (LY2811376). Plasma
                      proteomics using DIA showed a reduced abundance of soluble
                      FLT4 (sVEGFR3) for the non-specific inhbtor but not for the
                      BACE1 preferring inhibitor. Conclusively, sVEGFR3 is a
                      potential marker for BACE2 inhibition in plasma.},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/279490},
}