000279495 001__ 279495
000279495 005__ 20250709100939.0
000279495 037__ $$aDZNE-2025-00822
000279495 1001_ $$0P:(DE-2719)2810938$$aMüller, Stephan A$$b0$$udzne
000279495 245__ $$aDataset: Proteomic analysis of bone-marrow derived macrophages from NPC1 KO mice
000279495 260__ $$bPRoteomics IDEntifications Database$$c2024
000279495 3367_ $$2BibTeX$$aMISC
000279495 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1752047391_8071
000279495 3367_ $$026$$2EndNote$$aChart or Table
000279495 3367_ $$2DataCite$$aDataset
000279495 3367_ $$2ORCID$$aDATA_SET
000279495 3367_ $$2DINI$$aResearchData
000279495 520__ $$aNiemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in NPC1 gene, causing lipid accumulation within late endosomes/lysosomes, and resulting in progressive neurodegeneration. To study the effect of NPC1 deficiency on the innate immune system, we performed proteomics on bone-marrow derived macrophages (BMDMs) of NPC1 KO and WT mice. Without further treatment or activation, BMDMs of NPC1 KO mice showed alterations mainly related to cholesterol metabolism, which is in line with the intracellular cholesterol transport function of NPC1.
000279495 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000279495 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan$$b1$$udzne
000279495 7870_ $$0DZNE-2024-01395$$aDinkel, Lina et.al.$$dWashington, DC : AAAS, 2024$$iRelatedTo$$r$$tMyeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.
000279495 8564_ $$uhttps://wwwdev.ebi.ac.uk/pride/archive/projects/PXD056249
000279495 909CO $$ooai:pub.dzne.de:279495$$pVDB
000279495 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810938$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000279495 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2181459$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000279495 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000279495 9201_ $$0I:(DE-2719)1110006$$kAG Lichtenthaler$$lNeuroproteomics$$x0
000279495 980__ $$adataset
000279495 980__ $$aVDB
000279495 980__ $$aI:(DE-2719)1110006
000279495 980__ $$aUNRESTRICTED