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@MISC{Mller:279495,
author = {Müller, Stephan A and Lichtenthaler, Stefan},
title = {{D}ataset: {P}roteomic analysis of bone-marrow derived
macrophages from {NPC}1 {KO} mice},
publisher = {PRoteomics IDEntifications Database},
reportid = {DZNE-2025-00822},
year = {2024},
abstract = {Niemann-Pick type C (NPC) disease is an inherited lysosomal
storage disorder mainly driven by mutations in NPC1 gene,
causing lipid accumulation within late endosomes/lysosomes,
and resulting in progressive neurodegeneration. To study the
effect of NPC1 deficiency on the innate immune system, we
performed proteomics on bone-marrow derived macrophages
(BMDMs) of NPC1 KO and WT mice. Without further treatment or
activation, BMDMs of NPC1 KO mice showed alterations mainly
related to cholesterol metabolism, which is in line with the
intracellular cholesterol transport function of NPC1.},
cin = {AG Lichtenthaler},
cid = {I:(DE-2719)1110006},
pnm = {352 - Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)32},
url = {https://pub.dzne.de/record/279495},
}