000279880 001__ 279880
000279880 005__ 20250716101214.0
000279880 0247_ $$2doi$$a10.7554/eLife.101105
000279880 0247_ $$2pmid$$apmid:40643572
000279880 0247_ $$2pmc$$apmc:PMC12252544
000279880 037__ $$aDZNE-2025-00847
000279880 041__ $$aEnglish
000279880 082__ $$a600
000279880 1001_ $$00000-0002-1279-4800$$aCooper, Claire$$b0
000279880 245__ $$aUltraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.
000279880 260__ $$aCambridge$$beLife Sciences Publications$$c2025
000279880 3367_ $$2DRIVER$$aarticle
000279880 3367_ $$2DataCite$$aOutput Types/Journal article
000279880 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1752572044_17617
000279880 3367_ $$2BibTeX$$aARTICLE
000279880 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000279880 3367_ $$00$$2EndNote$$aJournal Article
000279880 520__ $$aBeyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings of extracellular 5-HT using a recently developed G-Protein-Coupled Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and local field potential in the hippocampal CA1 of mice, which revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT oscillations both during NREM and WAKE states. Interestingly, the phase of these ultraslow 5-HT oscillations was found to distinguish substates both within and across larger behavioral states. Hippocampal ripples occurred preferentially on the falling phase of ultraslow 5-HT oscillations during both NREM and WAKE, with higher power ripples concentrating near the peak specifically during NREM. By contrast, hippocampal-cortical coherence was strongest, and microarousals and intracranial EMG peaks were most prevalent during the rising phase in both wake and NREM. Overall, ultraslow 5-HT oscillations delineate substates within the larger behavioral states of NREM and WAKE, thus potentially temporally segregating internal memory consolidation processes from arousal-related functions.
000279880 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000279880 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000279880 650_7 $$2Other$$abehavioral state
000279880 650_7 $$2Other$$ahippocampus
000279880 650_7 $$2Other$$amouse
000279880 650_7 $$2Other$$aneuroscience
000279880 650_7 $$2Other$$aoscillation
000279880 650_7 $$2Other$$aripples
000279880 650_7 $$2Other$$aserotonin
000279880 650_7 $$0333DO1RDJY$$2NLM Chemicals$$aSerotonin
000279880 650_2 $$2MeSH$$aAnimals
000279880 650_2 $$2MeSH$$aSerotonin: metabolism
000279880 650_2 $$2MeSH$$aWakefulness: physiology
000279880 650_2 $$2MeSH$$aMice
000279880 650_2 $$2MeSH$$aHippocampus: physiology
000279880 650_2 $$2MeSH$$aMale
000279880 650_2 $$2MeSH$$aMice, Inbred C57BL
000279880 650_2 $$2MeSH$$aCA1 Region, Hippocampal: physiology
000279880 650_2 $$2MeSH$$aSleep
000279880 7001_ $$00000-0001-8775-024X$$aParthier, Daniel$$b1
000279880 7001_ $$00000-0001-6895-7405$$aSibille, Jeremie$$b2
000279880 7001_ $$0P:(DE-2719)2812696$$aTukker, Jan Johan$$b3
000279880 7001_ $$00000-0003-3181-7681$$aTritsch, Nicolas$$b4
000279880 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b5$$eLast author
000279880 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.101105$$gVol. 13, p. RP101105$$pRP101105$$teLife$$v13$$x2050-084X$$y2025
000279880 8564_ $$uhttps://pub.dzne.de/record/279880/files/DZNE-2025-00847%20SUP.pdf
000279880 8564_ $$uhttps://pub.dzne.de/record/279880/files/DZNE-2025-00847.pdf$$yOpenAccess
000279880 8564_ $$uhttps://pub.dzne.de/record/279880/files/DZNE-2025-00847%20SUP.pdf?subformat=pdfa$$xpdfa
000279880 8564_ $$uhttps://pub.dzne.de/record/279880/files/DZNE-2025-00847.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000279880 909CO $$ooai:pub.dzne.de:279880$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000279880 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812696$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000279880 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810725$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000279880 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000279880 9141_ $$y2025
000279880 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bELIFE : 2022$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-07-30T13:58:16Z
000279880 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-07-30T13:58:16Z
000279880 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000279880 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bELIFE : 2022$$d2024-12-28
000279880 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-28
000279880 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000279880 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-28
000279880 9201_ $$0I:(DE-2719)1810004$$kAG Schmitz$$lNetwork Dysfunction$$x0
000279880 980__ $$ajournal
000279880 980__ $$aVDB
000279880 980__ $$aUNRESTRICTED
000279880 980__ $$aI:(DE-2719)1810004
000279880 9801_ $$aFullTexts