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@ARTICLE{Cooper:279880,
      author       = {Cooper, Claire and Parthier, Daniel and Sibille, Jeremie
                      and Tukker, Jan Johan and Tritsch, Nicolas and Schmitz,
                      Dietmar},
      title        = {{U}ltraslow serotonin oscillations in the hippocampus
                      delineate substates across {NREM} and waking.},
      journal      = {eLife},
      volume       = {13},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2025-00847},
      pages        = {RP101105},
      year         = {2025},
      abstract     = {Beyond the vast array of functional roles attributed to
                      serotonin (5-HT) in the brain, changes in 5-HT levels have
                      been shown to accompany changes in behavioral states,
                      including WAKE, NREM, and REM sleep. Whether 5-HT dynamics
                      at shorter time scales can be seen to delineate substates
                      within these larger brain states remains an open question.
                      Here, we performed simultaneous recordings of extracellular
                      5-HT using a recently developed G-Protein-Coupled
                      Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and
                      local field potential in the hippocampal CA1 of mice, which
                      revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT
                      oscillations both during NREM and WAKE states.
                      Interestingly, the phase of these ultraslow 5-HT
                      oscillations was found to distinguish substates both within
                      and across larger behavioral states. Hippocampal ripples
                      occurred preferentially on the falling phase of ultraslow
                      5-HT oscillations during both NREM and WAKE, with higher
                      power ripples concentrating near the peak specifically
                      during NREM. By contrast, hippocampal-cortical coherence was
                      strongest, and microarousals and intracranial EMG peaks were
                      most prevalent during the rising phase in both wake and
                      NREM. Overall, ultraslow 5-HT oscillations delineate
                      substates within the larger behavioral states of NREM and
                      WAKE, thus potentially temporally segregating internal
                      memory consolidation processes from arousal-related
                      functions.},
      keywords     = {Animals / Serotonin: metabolism / Wakefulness: physiology /
                      Mice / Hippocampus: physiology / Male / Mice, Inbred C57BL /
                      CA1 Region, Hippocampal: physiology / Sleep / behavioral
                      state (Other) / hippocampus (Other) / mouse (Other) /
                      neuroscience (Other) / oscillation (Other) / ripples (Other)
                      / serotonin (Other) / Serotonin (NLM Chemicals)},
      cin          = {AG Schmitz},
      ddc          = {600},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40643572},
      pmc          = {pmc:PMC12252544},
      doi          = {10.7554/eLife.101105},
      url          = {https://pub.dzne.de/record/279880},
}