Home > Publications Database > Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking. > print

001     279880
005     20250716101214.0
024 7 _ |a 10.7554/eLife.101105
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037 _ _ |a DZNE-2025-00847
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082 _ _ |a 600
100 1 _ |a Cooper, Claire
|0 0000-0002-1279-4800
|b 0
245 _ _ |a Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.
260 _ _ |a Cambridge
|c 2025
|b eLife Sciences Publications
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520 _ _ |a Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings of extracellular 5-HT using a recently developed G-Protein-Coupled Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and local field potential in the hippocampal CA1 of mice, which revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT oscillations both during NREM and WAKE states. Interestingly, the phase of these ultraslow 5-HT oscillations was found to distinguish substates both within and across larger behavioral states. Hippocampal ripples occurred preferentially on the falling phase of ultraslow 5-HT oscillations during both NREM and WAKE, with higher power ripples concentrating near the peak specifically during NREM. By contrast, hippocampal-cortical coherence was strongest, and microarousals and intracranial EMG peaks were most prevalent during the rising phase in both wake and NREM. Overall, ultraslow 5-HT oscillations delineate substates within the larger behavioral states of NREM and WAKE, thus potentially temporally segregating internal memory consolidation processes from arousal-related functions.
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650 _ 7 |a behavioral state
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650 _ 7 |a hippocampus
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650 _ 7 |a mouse
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650 _ 7 |a neuroscience
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650 _ 7 |a oscillation
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650 _ 7 |a ripples
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650 _ 7 |a serotonin
|2 Other
650 _ 7 |a Serotonin
|0 333DO1RDJY
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Serotonin: metabolism
|2 MeSH
650 _ 2 |a Wakefulness: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a CA1 Region, Hippocampal: physiology
|2 MeSH
650 _ 2 |a Sleep
|2 MeSH
700 1 _ |a Parthier, Daniel
|0 0000-0001-8775-024X
|b 1
700 1 _ |a Sibille, Jeremie
|0 0000-0001-6895-7405
|b 2
700 1 _ |a Tukker, Jan Johan
|0 P:(DE-2719)2812696
|b 3
700 1 _ |a Tritsch, Nicolas
|0 0000-0003-3181-7681
|b 4
700 1 _ |a Schmitz, Dietmar
|0 P:(DE-2719)2810725
|b 5
|e Last author
773 _ _ |a 10.7554/eLife.101105
|g Vol. 13, p. RP101105
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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