TY - JOUR
AU - Giona, Federica
AU - Beretta, Stefania
AU - Zippo, Antonio
AU - Stefanoni, Alessia
AU - Tomasoni, Zaira
AU - Vicidomini, Cinzia
AU - Ponzoni, Luisa
AU - Sala, Mariaelvina
AU - Jones, Carrie K
AU - Conn, P Jeffrey
AU - Boeckers, Tobias M
AU - Sala, Carlo
AU - Verpelli, Chiara
TI - Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome.
JO - Molecular psychiatry
VL - 30
IS - 8
SN - 1359-4184
CY - [London]
PB - Springer Nature
M1 - DZNE-2025-00849
SP - 3599 - 3614
PY - 2025
AB - Mutations or deletions in the SHANK3 gene have been identified in up to 1
KW - Animals
KW - Nerve Tissue Proteins: metabolism
KW - Nerve Tissue Proteins: genetics
KW - Mice, Knockout
KW - Humans
KW - Mice
KW - Ribosomal Proteins: metabolism
KW - Ribosomal Proteins: genetics
KW - Receptor, Metabotropic Glutamate 5: metabolism
KW - Receptor, Metabotropic Glutamate 5: genetics
KW - Chromosome Disorders: metabolism
KW - Chromosome Disorders: genetics
KW - Protein Biosynthesis
KW - Induced Pluripotent Stem Cells: metabolism
KW - Neurons: metabolism
KW - Chromosomes, Human, Pair 22: genetics
KW - Chromosome Deletion
KW - Corpus Striatum: metabolism
KW - Male
KW - Autism Spectrum Disorder: metabolism
KW - Cerebral Cortex: metabolism
KW - Down-Regulation
KW - Disease Models, Animal
KW - Microfilament Proteins
KW - Nerve Tissue Proteins (NLM Chemicals)
KW - Shank3 protein, mouse (NLM Chemicals)
KW - Ribosomal Proteins (NLM Chemicals)
KW - Receptor, Metabotropic Glutamate 5 (NLM Chemicals)
KW - SHANK3 protein, human (NLM Chemicals)
KW - Microfilament Proteins (NLM Chemicals)
LB - PUB:(DE-HGF)16
C6 - pmid:40089604
C2 - pmc:PMC12240844
DO - DOI:10.1038/s41380-025-02947-9
UR - https://pub.dzne.de/record/279882
ER -