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@ARTICLE{Abdelmotaleb:279883,
      author       = {Abdelmotaleb, Mohamed and Niemann, Filip and Kocataş,
                      Harun and Caisachana Guevara, Leonardo M and Shahbabaie,
                      Alireza and Malinowski, Robert and Riemann, Steffen and
                      Fromm, Anna Elisabeth and Hayek, Dayana and Antonenko, Daria
                      and Meinzer, Marcus and Flöel, Agnes},
      title        = {{I}dentification of {R}eliable {T}arget {B}rain {R}egions
                      for {E}nhancing {O}bject-{L}ocation {M}emory by {B}rain
                      {S}timulation.},
      journal      = {Brain and behavior},
      volume       = {15},
      number       = {7},
      issn         = {2162-3279},
      address      = {Malden, Mass.},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00850},
      pages        = {e70658},
      year         = {2025},
      abstract     = {Object-location memory (OLM) is essential for remembering
                      the locations of objects within an environment and is often
                      impaired in aging and neurodegenerative diseases.
                      Transcranial direct current stimulation (tDCS) has shown
                      promise for improving OLM, although study outcomes have
                      varied considerably. This study aimed to identify key brain
                      regions involved in OLM that may serve as stimulation
                      targets for future tDCS research and to assess the
                      test-retest reliability (TRR) of both behavioral and
                      functional magnetic resonance imaging (fMRI) data.Twenty
                      healthy young adults (10 females; mean age = 25.0 years,
                      standard deviation [SD] = 5.56) completed two task-based
                      fMRI sessions using parallel versions of an OLM task.
                      Participants learned associations between house images and
                      their locations on a two-dimensional street map across four
                      feedback-based learning stages. Sham tDCS was administered
                      in both sessions using a focal 3 × 1 electrode montage. TRR
                      was assessed using intraclass correlation coefficients
                      (ICCs) for behavioral performance and task-related fMRI
                      activation.Behavioral data showed significant improvements
                      in response accuracy (estimate = 0.211, p < 0.001) and a
                      reduction in response latency (estimate = -0.050, p < 0.001)
                      across learning stages. fMRI analysis revealed predominantly
                      right-lateralized activation, including the right
                      hippocampus, the fusiform gyrus, the precuneus, and the
                      lateral temporo-occipital areas. Behavioral measures showed
                      moderate to good TRR (accuracy ICC = 0.801; reaction time
                      ICC = 0.705). Task-related fMRI activity demonstrated
                      good-to-excellent TRR in key regions, including the fusiform
                      and temporo-occipital cortices.These findings support the
                      validity of our OLM paradigm for assessing brain stimulation
                      effects and highlight potential cortical targets for future
                      tDCS interventions. The observed reliability of behavioral
                      and neural measures further reinforces the utility of this
                      protocol in crossover study designs.},
      keywords     = {Humans / Female / Transcranial Direct Current Stimulation:
                      methods / Magnetic Resonance Imaging: methods / Male / Adult
                      / Young Adult / Brain: physiology / Brain: diagnostic
                      imaging / Reproducibility of Results / Brain Mapping:
                      methods / Spatial Memory: physiology / functional magnetic
                      resonance imaging (fMRI) (Other) / object–location memory
                      (OLM) (Other) / test–retest reliability (TRR) (Other) /
                      transcranial direct current stimulation (tDCS) (Other)},
      cin          = {AG Flöel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000081},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40635372},
      pmc          = {pmc:PMC12241688},
      doi          = {10.1002/brb3.70658},
      url          = {https://pub.dzne.de/record/279883},
}