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001     279883
005     20250716101214.0
024 7 _ |a 10.1002/brb3.70658
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041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Abdelmotaleb, Mohamed
|0 0009-0007-3552-7266
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245 _ _ |a Identification of Reliable Target Brain Regions for Enhancing Object-Location Memory by Brain Stimulation.
260 _ _ |a Malden, Mass.
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520 _ _ |a Object-location memory (OLM) is essential for remembering the locations of objects within an environment and is often impaired in aging and neurodegenerative diseases. Transcranial direct current stimulation (tDCS) has shown promise for improving OLM, although study outcomes have varied considerably. This study aimed to identify key brain regions involved in OLM that may serve as stimulation targets for future tDCS research and to assess the test-retest reliability (TRR) of both behavioral and functional magnetic resonance imaging (fMRI) data.Twenty healthy young adults (10 females; mean age = 25.0 years, standard deviation [SD] = 5.56) completed two task-based fMRI sessions using parallel versions of an OLM task. Participants learned associations between house images and their locations on a two-dimensional street map across four feedback-based learning stages. Sham tDCS was administered in both sessions using a focal 3 × 1 electrode montage. TRR was assessed using intraclass correlation coefficients (ICCs) for behavioral performance and task-related fMRI activation.Behavioral data showed significant improvements in response accuracy (estimate = 0.211, p < 0.001) and a reduction in response latency (estimate = -0.050, p < 0.001) across learning stages. fMRI analysis revealed predominantly right-lateralized activation, including the right hippocampus, the fusiform gyrus, the precuneus, and the lateral temporo-occipital areas. Behavioral measures showed moderate to good TRR (accuracy ICC = 0.801; reaction time ICC = 0.705). Task-related fMRI activity demonstrated good-to-excellent TRR in key regions, including the fusiform and temporo-occipital cortices.These findings support the validity of our OLM paradigm for assessing brain stimulation effects and highlight potential cortical targets for future tDCS interventions. The observed reliability of behavioral and neural measures further reinforces the utility of this protocol in crossover study designs.
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650 _ 7 |a functional magnetic resonance imaging (fMRI)
|2 Other
650 _ 7 |a object–location memory (OLM)
|2 Other
650 _ 7 |a test–retest reliability (TRR)
|2 Other
650 _ 7 |a transcranial direct current stimulation (tDCS)
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Transcranial Direct Current Stimulation: methods
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Brain: physiology
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Reproducibility of Results
|2 MeSH
650 _ 2 |a Brain Mapping: methods
|2 MeSH
650 _ 2 |a Spatial Memory: physiology
|2 MeSH
700 1 _ |a Niemann, Filip
|b 1
700 1 _ |a Kocataş, Harun
|b 2
700 1 _ |a Caisachana Guevara, Leonardo M
|b 3
700 1 _ |a Shahbabaie, Alireza
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700 1 _ |a Malinowski, Robert
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700 1 _ |a Riemann, Steffen
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700 1 _ |a Fromm, Anna Elisabeth
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700 1 _ |a Hayek, Dayana
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700 1 _ |a Antonenko, Daria
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700 1 _ |a Meinzer, Marcus
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700 1 _ |a Flöel, Agnes
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773 _ _ |a 10.1002/brb3.70658
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