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000280026 1001_ $$0P:(DE-2719)9001591$$aBremer, Anna-Sophie$$b0$$eFirst author$$udzne
000280026 245__ $$aTranscriptomic profile of microglia following inflammation-sensitized hypoxic-ischemic brain injury in neonatal rats suggests strong contribution to neutrophil chemotaxis and activation.
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000280026 520__ $$aInflammation-sensitized hypoxic-ischemic brain injury significantly contributes to neonatal mortality as affected neonates do not benefit from standard cooling treatments. To get further insight into inflammatory responses involved, we experimentally investigated the immune response of microglia in an inflammation-sensitized neonatal hypoxia-ischemia (HI) model.Transcriptomic analysis of microglia isolated from brains following inflammation-sensitized HI brain injury revealed a strong upregulation of leukocyte recruitment and pro-inflammatory markers. Specifically, markers associated with neutrophil-mediated immune responses and chemotaxis were upregulated in the inflammation-sensitized HI group compared to the non-inflammation-sensitized HI and control groups. Serpine 1 and Selp could be identified as specifically upregulated markers indicating an acute inflammatory condition before HI injury.Our study revealed preliminary data about a microglia population which is primed to recruit peripheral neutrophils to infiltrate the brain and mediate neutrophil immune response. We showed a contribution to neutrophil activation in case of inflammation following HI in the brain. Targeting microglia-mediated neutrophil recruitment can indicate a possible treatment approach in case of inflammation-sensitized HI brain injury.
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000280026 650_7 $$2Other$$aBrain inflammation
000280026 650_7 $$2Other$$aMicroglia priming
000280026 650_7 $$2Other$$aNeonatal Hypoxia-Ischemia
000280026 650_7 $$2Other$$aNeutrophil recruitment
000280026 650_7 $$2Other$$aTranscriptomic analysis
000280026 650_2 $$2MeSH$$aAnimals
000280026 650_2 $$2MeSH$$aMicroglia: metabolism
000280026 650_2 $$2MeSH$$aMicroglia: pathology
000280026 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: pathology
000280026 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: metabolism
000280026 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: immunology
000280026 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: genetics
000280026 650_2 $$2MeSH$$aAnimals, Newborn
000280026 650_2 $$2MeSH$$aRats
000280026 650_2 $$2MeSH$$aNeutrophils: metabolism
000280026 650_2 $$2MeSH$$aNeutrophils: immunology
000280026 650_2 $$2MeSH$$aTranscriptome: physiology
000280026 650_2 $$2MeSH$$aInflammation: pathology
000280026 650_2 $$2MeSH$$aInflammation: metabolism
000280026 650_2 $$2MeSH$$aNeutrophil Activation: physiology
000280026 650_2 $$2MeSH$$aChemotaxis: physiology
000280026 650_2 $$2MeSH$$aGene Expression Profiling
000280026 650_2 $$2MeSH$$aRats, Sprague-Dawley
000280026 7001_ $$0P:(DE-2719)9003171$$aHenschel, Nico$$b1$$udzne
000280026 7001_ $$0P:(DE-2719)9002524$$aBurkard, Hannah$$b2$$udzne
000280026 7001_ $$0P:(DE-2719)2810557$$aBernis, Maria Eugenia$$b3$$udzne
000280026 7001_ $$0P:(DE-2719)9000845$$aUlas, Thomas$$b4$$udzne
000280026 7001_ $$0P:(DE-2719)9000732$$aSabir, Hemmen$$b5$$eLast author$$udzne
000280026 773__ $$0PERI:(DE-600)2156455-3$$a10.1186/s12974-025-03516-1$$gVol. 22, no. 1, p. 189$$n1$$p189$$tJournal of neuroinflammation$$v22$$x1742-2094$$y2025
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