TY  - JOUR
AU  - Preßler, Hannah
AU  - Bünger, Isabel
AU  - Prüss, Harald
TI  - Novel cerebrospinal fluid anti-central nervous system IgG antibodies can identify immunotherapy-responsive neuropsychiatric disorders.
JO  - Frontiers in immunology
VL  - 16
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2025-00884
SP  - 1612844
PY  - 2025
AB  - Autoantibodies (Abs) targeting the central nervous system (CNS) can cause various neuropsychiatric autoimmune diseases. The potential response to immunotherapy necessitates the continuous expansion of Ab testing strategies including non-antigen-specific screening assays. This study investigated whether tissue-based screening using unfixed murine CNS sections can help to identify patients with immunotherapy-responsive neuropsychiatric diseases after routine Ab panels yielded negative results.This retrospective single-center study screened cerebrospinal fluid (CSF) of 279 patients for immunoglobulin G (IgG) anti-CNS Abs using unfixed mouse brain. Patients had a variety of neuropsychiatric conditions, in which an autoimmune contribution was considered. Previous testing for a panel of established autoantibodies using cell-based assays remained negative. Of 238 patients, paired serum samples were available.A subgroup of 55 patients (20
KW  - Humans
KW  - Autoantibodies: cerebrospinal fluid
KW  - Autoantibodies: immunology
KW  - Female
KW  - Immunoglobulin G: cerebrospinal fluid
KW  - Immunoglobulin G: immunology
KW  - Male
KW  - Middle Aged
KW  - Retrospective Studies
KW  - Immunotherapy: methods
KW  - Adult
KW  - Animals
KW  - Aged
KW  - Mice
KW  - Mental Disorders: cerebrospinal fluid
KW  - Mental Disorders: immunology
KW  - Mental Disorders: therapy
KW  - Mental Disorders: diagnosis
KW  - Young Adult
KW  - Biomarkers: cerebrospinal fluid
KW  - Adolescent
KW  - Central Nervous System: immunology
KW  - autoimmune neurology and psychiatry (Other)
KW  - immunofluorescence (Other)
KW  - immunotherapy (Other)
KW  - novel anti neuronal autoantibodies (Other)
KW  - seronegative autoimmune encephalitis (Other)
KW  - Autoantibodies (NLM Chemicals)
KW  - Immunoglobulin G (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40692787
C2  - pmc:PMC12277280
DO  - DOI:10.3389/fimmu.2025.1612844
UR  - https://pub.dzne.de/record/280045
ER  -