TY - JOUR
AU - Preßler, Hannah
AU - Bünger, Isabel
AU - Prüss, Harald
TI - Novel cerebrospinal fluid anti-central nervous system IgG antibodies can identify immunotherapy-responsive neuropsychiatric disorders.
JO - Frontiers in immunology
VL - 16
SN - 1664-3224
CY - Lausanne
PB - Frontiers Media
M1 - DZNE-2025-00884
SP - 1612844
PY - 2025
AB - Autoantibodies (Abs) targeting the central nervous system (CNS) can cause various neuropsychiatric autoimmune diseases. The potential response to immunotherapy necessitates the continuous expansion of Ab testing strategies including non-antigen-specific screening assays. This study investigated whether tissue-based screening using unfixed murine CNS sections can help to identify patients with immunotherapy-responsive neuropsychiatric diseases after routine Ab panels yielded negative results.This retrospective single-center study screened cerebrospinal fluid (CSF) of 279 patients for immunoglobulin G (IgG) anti-CNS Abs using unfixed mouse brain. Patients had a variety of neuropsychiatric conditions, in which an autoimmune contribution was considered. Previous testing for a panel of established autoantibodies using cell-based assays remained negative. Of 238 patients, paired serum samples were available.A subgroup of 55 patients (20
KW - Humans
KW - Autoantibodies: cerebrospinal fluid
KW - Autoantibodies: immunology
KW - Female
KW - Immunoglobulin G: cerebrospinal fluid
KW - Immunoglobulin G: immunology
KW - Male
KW - Middle Aged
KW - Retrospective Studies
KW - Immunotherapy: methods
KW - Adult
KW - Animals
KW - Aged
KW - Mice
KW - Mental Disorders: cerebrospinal fluid
KW - Mental Disorders: immunology
KW - Mental Disorders: therapy
KW - Mental Disorders: diagnosis
KW - Young Adult
KW - Biomarkers: cerebrospinal fluid
KW - Adolescent
KW - Central Nervous System: immunology
KW - autoimmune neurology and psychiatry (Other)
KW - immunofluorescence (Other)
KW - immunotherapy (Other)
KW - novel anti neuronal autoantibodies (Other)
KW - seronegative autoimmune encephalitis (Other)
KW - Autoantibodies (NLM Chemicals)
KW - Immunoglobulin G (NLM Chemicals)
KW - Biomarkers (NLM Chemicals)
LB - PUB:(DE-HGF)16
C6 - pmid:40692787
C2 - pmc:PMC12277280
DO - DOI:10.3389/fimmu.2025.1612844
UR - https://pub.dzne.de/record/280045
ER -