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@ARTICLE{Baumeister:280047,
      author       = {Baumeister, Hannah and Gellersen, Helena M and Polk, Sarah
                      E and Lattmann, René and Wuestefeld, Anika and Wisse, Laura
                      E M and Glenn, Trevor and Yakupov, Renat and Stark, Melina
                      and Kleineidam, Luca and Roeske, Sandra and Marcos Morgado,
                      Barbara and Esselmann, Hermann and Brosseron, Frederic and
                      Ramirez, Alfredo and Lüsebrink, Falk and Synofzik, Matthis
                      and Schott, Björn H and Schmid, Matthias C and Hetzer,
                      Stefan and Dechent, Peter and Scheffler, Klaus and Ewers,
                      Michael and Hellmann-Regen, Julian and Ersözlü, Ersin and
                      Spruth, Eike Jakob and Gemenetzi, Maria and Fliessbach,
                      Klaus and Bartels, Claudia and Rostamzadeh, Ayda and Glanz,
                      Wenzel and Incesoy, Enise I and Janowitz, Daniel and
                      Rauchmann, Boris Stephan and Kilimann, Ingo and Sodenkamp,
                      Sebastian and Coenjaerts, Marie and Spottke, Annika and
                      Peters, Oliver and Priller, Josef and Schneider, Anja and
                      Wiltfang, Jens and Buerger, Katharina and Perneczky, Robert
                      and Teipel, Stefan and Laske, Christoph and Wagner, Michael
                      and Ziegler, Gabriel and Jessen, Frank and Düzel, Emrah and
                      Berron, David},
      collaboration = {group, DELCODE study},
      title        = {{D}isease stage-specific atrophy markers in {A}lzheimer's
                      disease.},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {7},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00886},
      pages        = {e70482},
      year         = {2025},
      abstract     = {Structural magnetic resonance imaging (MRI) often lacks
                      diagnostic, prognostic, and monitoring value in Alzheimer's
                      disease (AD), particularly in early disease stages. To
                      improve its utility, we aimed to identify optimal atrophy
                      markers for different intended uses.We included 363 older
                      adults; cognitively unimpaired individuals who were negative
                      or positive for amyloid beta (Aβ) and Aβ-positive patients
                      with subjective cognitive decline, mild cognitive
                      impairment, or dementia of the Alzheimer type. MRI and
                      neuropsychological assessments were administered annually
                      for up to 3 years.Accelerated atrophy of medial temporal
                      lobe subregions was evident already during preclinical AD.
                      Symptomatic disease stages most notably differed in their
                      hippocampal and parietal atrophy signatures.
                      Atrophy-cognition relationships varied by intended use and
                      disease stage.With the appropriate marker, MRI can detect
                      abnormal atrophy already during preclinical AD. To optimize
                      performance, atrophy markers should be tailored to the
                      targeted disease stage and intended use.Subregional atrophy
                      markers detect ongoing atrophy in preclinical Alzheimer's
                      disease (AD). Subjective cognitive decline in preclinical AD
                      links to manifest atrophy. Optimal atrophy markers differ by
                      the disease stage and intended use.},
      keywords     = {Humans / Alzheimer Disease: pathology / Alzheimer Disease:
                      diagnostic imaging / Atrophy: pathology / Magnetic Resonance
                      Imaging / Male / Female / Aged / Cognitive Dysfunction:
                      pathology / Cognitive Dysfunction: diagnostic imaging /
                      Neuropsychological Tests / Biomarkers / Amyloid
                      beta-Peptides / Brain: pathology / Brain: diagnostic imaging
                      / Disease Progression / Aged, 80 and over / Hippocampus:
                      pathology / imaging biomarker (Other) / longitudinal atrophy
                      (Other) / magnetic resonance imaging (Other) / medial
                      temporal lobe (Other) / parietal lobe (Other) / Biomarkers
                      (NLM Chemicals) / Amyloid beta-Peptides (NLM Chemicals)},
      cin          = {AG Berron / AG Düzel / AG Wagner / AG Heneka / Patient
                      Studies (Bonn) / AG Gasser / AG Fischer / AG Schmid Bonn /
                      AG Endres / AG Dirnagl / AG Teipel / ICRU / AG Spottke /
                      Clinical Research Platform (CRP) / AG Peters / AG Priller /
                      AG Schneider / AG Wiltfang / Clinical Research (Munich) / AG
                      Dichgans / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)5000070 / I:(DE-2719)5000006 /
                      I:(DE-2719)1011201 / I:(DE-2719)1011303 / I:(DE-2719)1011101
                      / I:(DE-2719)1210000 / I:(DE-2719)1410002 /
                      I:(DE-2719)1013028 / I:(DE-2719)1811005 / I:(DE-2719)1810002
                      / I:(DE-2719)1510100 / I:(DE-2719)1240005 /
                      I:(DE-2719)1011103 / I:(DE-2719)1011401 / I:(DE-2719)5000000
                      / I:(DE-2719)5000007 / I:(DE-2719)1011305 /
                      I:(DE-2719)1410006 / I:(DE-2719)1111015 / I:(DE-2719)5000022
                      / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40691867},
      doi          = {10.1002/alz.70482},
      url          = {https://pub.dzne.de/record/280047},
}