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000280050 1001_ $$00000-0001-5503-1742$$aSteinfurth, Laura$$b0
000280050 245__ $$aSelf-assessment of amyotrophic lateral sclerosis functional rating scale on the patient's smartphone proves to be non-inferior to clinic data capture.
000280050 260__ $$aAbingdon$$bTaylor Francis Group$$c2025
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000280050 520__ $$aTo investigate self-assessment of the amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) using the patient's smartphone and to analyze non-inferiority to clinic assessment.In an observational study, ALSFRS-R data being remotely collected on a mobile application (App-ALSFRS-R) were compared to ALSFRS-R captured during clinic visits (clinic-ALSFRS-R). ALS progression rate (ALSPR)-as calculated by the monthly decline of ALSFRS-R-and its intrasubject variability (ALSPR-ISV) between ratings were used to compare both cohorts. To investigate non-inferiority of App-ALSFRS-R data, a non-inferiority margin was determined.A total of 691 ALS patients using the ALS-App and 1895 patients with clinic assessments were included. Clinical characteristics for the App-ALSFRS-R and clinic-ALSFRS-R cohorts were as follows: Mean age 60.45 (SD 10.43) and 63.69 (SD 11.30) years (p < 0.001), disease duration 38.7 (SD 37.68) and 56.75 (SD 54.34) months (p < 0.001) and ALSPR 0.72 and 0.59 (p < 0.001), respectively. A paired sample analysis of ALSPR-ISV was applicable for 398 patients with clinic as well as app assessments and did not show a significant difference (IQR 0.12 [CI 0.11, 0.14] vs 0.12 [CI 0.11, 0.14], p = 0.24; Cohen's d = 0.06). CI of IQR for App-ALSFRS-R was below the predefined non-inferiority margin of 0.15 IQR, demonstrating non-inferiority.Patients using a mobile application for remote digital self-assessment of the ALSFRS-R revealed younger age, earlier disease course, and faster ALS progression. The finding of non-inferiority of App-ALSFRS-R assessments underscores, that data collection using the ALS-App on the patient's smartphone can serve as additional source of ALSFRS-R in ALS research and clinical practice.
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000280050 650_7 $$2Other$$aALS-App
000280050 650_7 $$2Other$$aAmyotrophic lateral sclerosis
000280050 650_7 $$2Other$$aamyotrophic lateral sclerosis functional rating scale-revised
000280050 650_7 $$2Other$$aremote assessment
000280050 650_7 $$2Other$$aself-assessment
000280050 650_2 $$2MeSH$$aHumans
000280050 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: diagnosis
000280050 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: psychology
000280050 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: physiopathology
000280050 650_2 $$2MeSH$$aMale
000280050 650_2 $$2MeSH$$aSmartphone
000280050 650_2 $$2MeSH$$aFemale
000280050 650_2 $$2MeSH$$aMiddle Aged
000280050 650_2 $$2MeSH$$aAged
000280050 650_2 $$2MeSH$$aMobile Applications
000280050 650_2 $$2MeSH$$aSelf-Assessment
000280050 650_2 $$2MeSH$$aDisease Progression
000280050 650_2 $$2MeSH$$aSeverity of Illness Index
000280050 650_2 $$2MeSH$$aCohort Studies
000280050 7001_ $$aGrehl, Torsten$$b1
000280050 7001_ $$aWeyen, Ute$$b2
000280050 7001_ $$aKettemann, Dagmar$$b3
000280050 7001_ $$aSteinbach, Robert$$b4
000280050 7001_ $$aRödiger, Annekathrin$$b5
000280050 7001_ $$aGrosskreutz, Julian$$b6
000280050 7001_ $$aPetri, Susanne$$b7
000280050 7001_ $$aBoentert, Matthias$$b8
000280050 7001_ $$0P:(DE-2719)9001116$$aWeydt, Patrick$$b9$$udzne
000280050 7001_ $$0P:(DE-2719)9000485$$aBernsen, Sarah$$b10$$udzne
000280050 7001_ $$aWalter, Bertram$$b11
000280050 7001_ $$0P:(DE-2719)2811849$$aGüNTHER, René$$b12$$udzne
000280050 7001_ $$0P:(DE-2719)2812561$$aLingor, Paul$$b13
000280050 7001_ $$aKoch, Jan Christoph$$b14
000280050 7001_ $$aBaum, Petra$$b15
000280050 7001_ $$aWeishaupt, Jochen H$$b16
000280050 7001_ $$0P:(DE-2719)9001951$$aDorst, Johannes$$b17$$udzne
000280050 7001_ $$aKoc, Yasemin$$b18
000280050 7001_ $$aCordts, Isabell$$b19
000280050 7001_ $$aVidovic, Maximilian$$b20
000280050 7001_ $$aNorden, Jenny$$b21
000280050 7001_ $$aSchumann, Peggy$$b22
000280050 7001_ $$0P:(DE-2719)2812030$$aKörtvelyessy, Peter$$b23$$udzne
000280050 7001_ $$aSpittel, Susanne$$b24
000280050 7001_ $$aMünch, Christoph$$b25
000280050 7001_ $$aMaier, André$$b26
000280050 7001_ $$00000-0002-2736-7350$$aMeyer, Thomas$$b27
000280050 773__ $$0PERI:(DE-600)2705061-0$$a10.1080/21678421.2025.2468404$$gVol. 26, no. 5-6, p. 495 - 506$$n5-6$$p495 - 506$$tAmyotrophic lateral sclerosis & frontotemporal degeneration$$v26$$x2167-8421$$y2025
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