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| Home > Publications Database > Self-assessment of amyotrophic lateral sclerosis functional rating scale on the patient's smartphone proves to be non-inferior to clinic data capture. > print |
| 001 | 280050 | ||
| 005 | 20250824001729.0 | ||
| 024 | 7 | _ | |a 10.1080/21678421.2025.2468404 |2 doi |
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| 024 | 7 | _ | |a 2167-8421 |2 ISSN |
| 024 | 7 | _ | |a 2167-9223 |2 ISSN |
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| 037 | _ | _ | |a DZNE-2025-00887 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Steinfurth, Laura |0 0000-0001-5503-1742 |b 0 |
| 245 | _ | _ | |a Self-assessment of amyotrophic lateral sclerosis functional rating scale on the patient's smartphone proves to be non-inferior to clinic data capture. |
| 260 | _ | _ | |a Abingdon |c 2025 |b Taylor Francis Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1753362620_6042 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To investigate self-assessment of the amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) using the patient's smartphone and to analyze non-inferiority to clinic assessment.In an observational study, ALSFRS-R data being remotely collected on a mobile application (App-ALSFRS-R) were compared to ALSFRS-R captured during clinic visits (clinic-ALSFRS-R). ALS progression rate (ALSPR)-as calculated by the monthly decline of ALSFRS-R-and its intrasubject variability (ALSPR-ISV) between ratings were used to compare both cohorts. To investigate non-inferiority of App-ALSFRS-R data, a non-inferiority margin was determined.A total of 691 ALS patients using the ALS-App and 1895 patients with clinic assessments were included. Clinical characteristics for the App-ALSFRS-R and clinic-ALSFRS-R cohorts were as follows: Mean age 60.45 (SD 10.43) and 63.69 (SD 11.30) years (p < 0.001), disease duration 38.7 (SD 37.68) and 56.75 (SD 54.34) months (p < 0.001) and ALSPR 0.72 and 0.59 (p < 0.001), respectively. A paired sample analysis of ALSPR-ISV was applicable for 398 patients with clinic as well as app assessments and did not show a significant difference (IQR 0.12 [CI 0.11, 0.14] vs 0.12 [CI 0.11, 0.14], p = 0.24; Cohen's d = 0.06). CI of IQR for App-ALSFRS-R was below the predefined non-inferiority margin of 0.15 IQR, demonstrating non-inferiority.Patients using a mobile application for remote digital self-assessment of the ALSFRS-R revealed younger age, earlier disease course, and faster ALS progression. The finding of non-inferiority of App-ALSFRS-R assessments underscores, that data collection using the ALS-App on the patient's smartphone can serve as additional source of ALSFRS-R in ALS research and clinical practice. |
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| 650 | _ | 7 | |a ALS-App |2 Other |
| 650 | _ | 7 | |a Amyotrophic lateral sclerosis |2 Other |
| 650 | _ | 7 | |a amyotrophic lateral sclerosis functional rating scale-revised |2 Other |
| 650 | _ | 7 | |a remote assessment |2 Other |
| 650 | _ | 7 | |a self-assessment |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Amyotrophic Lateral Sclerosis: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Amyotrophic Lateral Sclerosis: psychology |2 MeSH |
| 650 | _ | 2 | |a Amyotrophic Lateral Sclerosis: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Smartphone |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Mobile Applications |2 MeSH |
| 650 | _ | 2 | |a Self-Assessment |2 MeSH |
| 650 | _ | 2 | |a Disease Progression |2 MeSH |
| 650 | _ | 2 | |a Severity of Illness Index |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 700 | 1 | _ | |a Grehl, Torsten |b 1 |
| 700 | 1 | _ | |a Weyen, Ute |b 2 |
| 700 | 1 | _ | |a Kettemann, Dagmar |b 3 |
| 700 | 1 | _ | |a Steinbach, Robert |b 4 |
| 700 | 1 | _ | |a Rödiger, Annekathrin |b 5 |
| 700 | 1 | _ | |a Grosskreutz, Julian |b 6 |
| 700 | 1 | _ | |a Petri, Susanne |b 7 |
| 700 | 1 | _ | |a Boentert, Matthias |b 8 |
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| 700 | 1 | _ | |a Walter, Bertram |b 11 |
| 700 | 1 | _ | |a GüNTHER, René |0 P:(DE-2719)2811849 |b 12 |u dzne |
| 700 | 1 | _ | |a Lingor, Paul |0 P:(DE-2719)2812561 |b 13 |
| 700 | 1 | _ | |a Koch, Jan Christoph |b 14 |
| 700 | 1 | _ | |a Baum, Petra |b 15 |
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| 700 | 1 | _ | |a Cordts, Isabell |b 19 |
| 700 | 1 | _ | |a Vidovic, Maximilian |b 20 |
| 700 | 1 | _ | |a Norden, Jenny |b 21 |
| 700 | 1 | _ | |a Schumann, Peggy |b 22 |
| 700 | 1 | _ | |a Körtvelyessy, Peter |0 P:(DE-2719)2812030 |b 23 |u dzne |
| 700 | 1 | _ | |a Spittel, Susanne |b 24 |
| 700 | 1 | _ | |a Münch, Christoph |b 25 |
| 700 | 1 | _ | |a Maier, André |b 26 |
| 700 | 1 | _ | |a Meyer, Thomas |0 0000-0002-2736-7350 |b 27 |
| 773 | _ | _ | |a 10.1080/21678421.2025.2468404 |g Vol. 26, no. 5-6, p. 495 - 506 |0 PERI:(DE-600)2705061-0 |n 5-6 |p 495 - 506 |t Amyotrophic lateral sclerosis & frontotemporal degeneration |v 26 |y 2025 |x 2167-8421 |
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