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000280052 1001_ $$00000-0003-1844-8279$$aElAbd, Hesham$$b0
000280052 245__ $$aT and B cell responses against Epstein-Barr virus in primary sclerosing cholangitis.
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000280052 520__ $$aPrimary sclerosing cholangitis (PSC) is an idiopathic, progressive and incurable liver disease. Here, we aimed for systematic analyses of adaptive immune responses in PSC. By profiling the T cell repertoires of 504 individuals with PSC and 904 healthy controls, we identified 1,008 clonotypes associated with PSC. A substantial fraction of these clonotypes was restricted to known PSC human leukocyte antigen susceptibility alleles and known to target Epstein-Barr virus (EBV) epitopes. We further utilized phage-immunoprecipitation sequencing to determine antibody epitope repertoires of 120 individuals with PSC and 202 healthy controls, which showed a higher burden of anti-EBV responses in PSC than controls. EBV-specific monoclonal antibodies isolated from B cells in PSC livers corroborated convergent B and T cell responses against EBV. By analyzing electronic health records of >116 million people, we identified an association between infectious mononucleosis and PSC (odds ratio, 12; 95% confidence interval, 6.3-22.9), suggesting a link between EBV and PSC.
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000280052 650_2 $$2MeSH$$aHumans
000280052 650_2 $$2MeSH$$aHerpesvirus 4, Human: immunology
000280052 650_2 $$2MeSH$$aCholangitis, Sclerosing: immunology
000280052 650_2 $$2MeSH$$aCholangitis, Sclerosing: virology
000280052 650_2 $$2MeSH$$aCholangitis, Sclerosing: genetics
000280052 650_2 $$2MeSH$$aB-Lymphocytes: immunology
000280052 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000280052 650_2 $$2MeSH$$aMale
000280052 650_2 $$2MeSH$$aFemale
000280052 650_2 $$2MeSH$$aAdult
000280052 650_2 $$2MeSH$$aEpstein-Barr Virus Infections: immunology
000280052 650_2 $$2MeSH$$aMiddle Aged
000280052 650_2 $$2MeSH$$aCase-Control Studies
000280052 650_2 $$2MeSH$$aInfectious Mononucleosis: immunology
000280052 650_2 $$2MeSH$$aInfectious Mononucleosis: complications
000280052 7001_ $$00000-0003-2066-7905$$aPesesky, Mitchell$$b1
000280052 7001_ $$aInnocenti, Gabriel$$b2
000280052 7001_ $$aChung, Brian K$$b3
000280052 7001_ $$aMahdy, Aya K H$$b4
000280052 7001_ $$aKriukova, Valeriia$$b5
000280052 7001_ $$aKulsvehagen, Laila$$b6
000280052 7001_ $$aStrobbe, Dennis$$b7
000280052 7001_ $$aStühler, Claudia$$b8
000280052 7001_ $$aMayr, Gabriele$$b9
000280052 7001_ $$00000-0001-6902-3153$$aMay, Damon H$$b10
000280052 7001_ $$00009-0002-8208-1141$$aPrinzensteiner, Melanie$$b11
000280052 7001_ $$00000-0002-0125-1173$$aSteiert, Tim A$$b12
000280052 7001_ $$00000-0002-3735-9872$$aTran, Florian$$b13
000280052 7001_ $$00000-0001-6200-2675$$aHadjihannas, Michel V$$b14
000280052 7001_ $$aGünther, Rainer$$b15
000280052 7001_ $$00000-0002-2635-6422$$aRosati, Elisa$$b16
000280052 7001_ $$00000-0002-1647-2526$$aMucha, Sören$$b17
000280052 7001_ $$aLieb, Wolfgang$$b18
000280052 7001_ $$00000-0003-0919-0237$$aZiemann, Malte$$b19
000280052 7001_ $$00000-0002-2618-3920$$aDempfle, Astrid$$b20
000280052 7001_ $$aBraun, Felix$$b21
000280052 7001_ $$aFolseraas, Trine$$b22
000280052 7001_ $$00000-0002-5900-8096$$aHov, Johannes R$$b23
000280052 7001_ $$00000-0001-6903-6878$$aMelum, Espen$$b24
000280052 7001_ $$aBacher, Petra$$b25
000280052 7001_ $$aSterneck, Martina$$b26
000280052 7001_ $$00000-0001-9736-1483$$aWeismüller, Tobias J$$b27
000280052 7001_ $$aLenzen, Henrike$$b28
000280052 7001_ $$aBokemeyer, Bernd$$b29
000280052 7001_ $$aHowie, Bryan$$b30
000280052 7001_ $$aRobins, Harlan S$$b31
000280052 7001_ $$00000-0002-6989-8002$$aRöcken, Christoph$$b32
000280052 7001_ $$0P:(DE-HGF)0$$aSchreiber, Stefan$$b33
000280052 7001_ $$00000-0002-2642-419X$$aKhanna, Nina$$b34
000280052 7001_ $$0P:(DE-2719)9003515$$aPröbstel, Anne-Katrin$$b35
000280052 7001_ $$00000-0002-4264-1928$$aSchramm, Christoph$$b36
000280052 7001_ $$aVogl, Thomas$$b37
000280052 7001_ $$00000-0002-8289-9931$$aKarlsen, Tom H$$b38
000280052 7001_ $$0P:(DE-2719)9001139$$aFranke, Andre$$b39
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