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@ARTICLE{ElAbd:280052,
      author       = {ElAbd, Hesham and Pesesky, Mitchell and Innocenti, Gabriel
                      and Chung, Brian K and Mahdy, Aya K H and Kriukova, Valeriia
                      and Kulsvehagen, Laila and Strobbe, Dennis and Stühler,
                      Claudia and Mayr, Gabriele and May, Damon H and
                      Prinzensteiner, Melanie and Steiert, Tim A and Tran, Florian
                      and Hadjihannas, Michel V and Günther, Rainer and Rosati,
                      Elisa and Mucha, Sören and Lieb, Wolfgang and Ziemann,
                      Malte and Dempfle, Astrid and Braun, Felix and Folseraas,
                      Trine and Hov, Johannes R and Melum, Espen and Bacher, Petra
                      and Sterneck, Martina and Weismüller, Tobias J and Lenzen,
                      Henrike and Bokemeyer, Bernd and Howie, Bryan and Robins,
                      Harlan S and Röcken, Christoph and Schreiber, Stefan and
                      Khanna, Nina and Pröbstel, Anne-Katrin and Schramm,
                      Christoph and Vogl, Thomas and Karlsen, Tom H and Franke,
                      Andre},
      title        = {{T} and {B} cell responses against {E}pstein-{B}arr virus
                      in primary sclerosing cholangitis.},
      journal      = {Nature medicine},
      volume       = {31},
      number       = {7},
      issn         = {1078-8956},
      address      = {[New York, NY]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00889},
      pages        = {2306 - 2316},
      year         = {2025},
      abstract     = {Primary sclerosing cholangitis (PSC) is an idiopathic,
                      progressive and incurable liver disease. Here, we aimed for
                      systematic analyses of adaptive immune responses in PSC. By
                      profiling the T cell repertoires of 504 individuals with PSC
                      and 904 healthy controls, we identified 1,008 clonotypes
                      associated with PSC. A substantial fraction of these
                      clonotypes was restricted to known PSC human leukocyte
                      antigen susceptibility alleles and known to target
                      Epstein-Barr virus (EBV) epitopes. We further utilized
                      phage-immunoprecipitation sequencing to determine antibody
                      epitope repertoires of 120 individuals with PSC and 202
                      healthy controls, which showed a higher burden of anti-EBV
                      responses in PSC than controls. EBV-specific monoclonal
                      antibodies isolated from B cells in PSC livers corroborated
                      convergent B and T cell responses against EBV. By analyzing
                      electronic health records of >116 million people, we
                      identified an association between infectious mononucleosis
                      and PSC (odds ratio, 12; $95\%$ confidence interval,
                      6.3-22.9), suggesting a link between EBV and PSC.},
      keywords     = {Humans / Herpesvirus 4, Human: immunology / Cholangitis,
                      Sclerosing: immunology / Cholangitis, Sclerosing: virology /
                      Cholangitis, Sclerosing: genetics / B-Lymphocytes:
                      immunology / T-Lymphocytes: immunology / Male / Female /
                      Adult / Epstein-Barr Virus Infections: immunology / Middle
                      Aged / Case-Control Studies / Infectious Mononucleosis:
                      immunology / Infectious Mononucleosis: complications},
      cin          = {AG Pröbstel},
      ddc          = {610},
      cid          = {I:(DE-2719)1013045},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40500415},
      pmc          = {pmc:PMC12283410},
      doi          = {10.1038/s41591-025-03692-w},
      url          = {https://pub.dzne.de/record/280052},
}