%0 Journal Article
%A Nicolas, Aude
%A Sherva, Richard
%A Grenier-Boley, Benjamin
%A Kim, Yoontae
%A Kikuchi, Masataka
%A Timsina, Jigyasha
%A de Rojas, Itziar
%A Dalmasso, María Carolina
%A Zhou, Xiaopu
%A Le Guen, Yann
%A Arboleda-Bustos, Carlos E
%A Camargos Bicalho, Maria Aparecida
%A Guerchet, Maëlenn
%A van der Lee, Sven
%A Goss, Monica
%A Castillo, Atahualpa
%A Bellenguez, Céline
%A Küçükali, Fahri
%A Satizabal, Claudia L
%A Fongang, Bernard
%A Yang, Qiong
%A Peters, Oliver
%A Schneider, Anja
%A Dichgans, Martin
%A Rujescu, Dan
%A Scherbaum, Norbert
%A Deckert, Jürgen
%A Riedel-Heller, Steffi
%A Hausner, Lucrezia
%A Molina-Porcel, Laura
%A Düzel, Emrah
%A Grimmer, Timo
%A Wiltfang, Jens
%A Heilmann-Heimbach, Stefanie
%A Moebus, Susanne
%A Tegos, Thomas
%A Scarmeas, Nikolaos
%A Dols-Icardo, Oriol
%A Moreno, Fermin
%A Pérez-Tur, Jordi
%A Bullido, María J
%A Pastor, Pau
%A Sánchez-Valle, Raquel
%A Álvarez, Victoria
%A Cao, Han
%A Ip, Nancy Y
%A Fu, Amy K Y
%A Ip, Fanny C F
%A Olivar, Natividad
%A Muchnik, Carolina
%A Cuesta, Carolina
%A Campanelli, Lorenzo
%A Solis, Patricia
%A Politis, Daniel Gustavo
%A Kochen, Silvia
%A Brusco, Luis Ignacio
%A Boada, Mercè
%A García-González, Pablo
%A Puerta, Raquel
%A Mir, Pablo
%A Real, Luis M
%A Piñol-Ripoll, Gerard
%A García-Alberca, Jose María
%A Royo, Jose Luís
%A Rodriguez-Rodriguez, Eloy
%A Soininen, Hilkka
%A Heikkinen, Sami
%A de Mendonça, Alexandre
%A Mehrabian, Shima
%A Traykov, Latchezar
%A Hort, Jakub
%A Vyhnalek, Martin
%A Rasmussen, Katrine Laura
%A Thomassen, Jesper Qvist
%A Pijnenburg, Yolande A L
%A Holstege, Henne
%A van Swieten, John C
%A Seelaar, Harro
%A Claassen, Jurgen A H R
%A Jansen, Willemijn J
%A Ramakers, Inez
%A Verhey, Frans
%A van der Lugt, Aad
%A Scheltens, Philip
%A Ortega-Rojas, Jenny
%A Concha Mera, Ana Gabriela
%A Mahecha, Maria F
%A Pardo, Rodrigo
%A Arboleda, Gonzalo
%A Bahrami, Shahram
%A Fominykh, Vera
%A Selbæk, Geir
%A Graff, Caroline
%A Papenberg, Goran
%A Giedraitis, Vilmantas
%A Boland, Anne
%A Deleuze, Jean-François
%A de Marco, Luiz Armando
%A de Moraes, Edgar Nunes
%A de Mattos Viana, Bernardo
%A Túlio Gualberto Cintra, Marco
%A Juarez-Cedillo, Teresa
%A Griswold, Anthony J
%A Forund, Tatiana
%A Haines, Jonathan
%A Farrer, Lindsay
%A DeStefano, Anita
%A Wijsman, Ellen
%A Mayeux, Richard
%A Pericak-Vance, Margaret
%A Kunkle, Brian
%A Goate, Alison
%A Schellenberg, Gerard D
%A Vardarajan, Badri
%A Wang, Li-San
%A Leung, Yuk Yee
%A Dalgard, Clifton L
%A Nicolas, Gael
%A Wallon, David
%A Dufouil, Carole
%A Pasquier, Florence
%A Hanon, Olivier
%A Debette, Stéphanie
%A Grünblatt, Edna
%A Popp, Julius
%A Angel, Bárbara
%A Gloger, Sergio
%A Chacon, Maria Victoria
%A Aranguiz, Rafael
%A Orellana, Paulina
%A Slachevsky, Andrea
%A Gonzalez-Billault, Christian
%A Albala, Cecilia
%A Fuentes, Patricio
%A Sachdev, Perminder
%A Mather, Karen A
%A Hauger, Richard L
%A Merritt, Victoria
%A Panizzon, Matthew
%A Zhang, Rui
%A Gaziano, J Michael
%A Ghidoni, Roberta
%A Galimberti, Daniela
%A Arosio, Beatrice
%A Mecocci, Patrizia
%A Solfrizzi, Vincenzo
%A Parnetti, Lucilla
%A Squassina, Alessio
%A Tremolizzo, Lucio
%A Borroni, Barbara
%A Nacmias, Benedetta
%A Caffarra, Paolo
%A Seripa, Davide
%A Rainero, Innocenzo
%A Daniele, Antonio
%A Piras, Fabrizio
%A Leonard, Hampton L
%A Yokoyama, Jenifer S
%A Nalls, Mike A
%A Miyashita, Akinori
%A Hara, Norikazu
%A Ozaki, Kouichi
%A Niida, Shumpei
%A Williams, Julie
%A Masullo, Carlo
%A Amouyel, Philippe
%A Preux, Pierre-Marie
%A Mbelesso, Pascal
%A Bandzouzi, Bébène
%A Saykin, Andy
%A Jessen, Frank
%A Kehoe, Patrick G
%A Van Duijn, Cornelia
%A Ben Salem, Nesrine
%A Frikke-Schmidt, Ruth
%A Cherni, Lotfi
%A Greicius, Michael D
%A Tsolaki, Magda
%A Sánchez-Juan, Pascual
%A Romano Silva, Marco Aurélio
%A Porter, Tenielle
%A Laws, Simon M
%A Sleegers, Kristel
%A Ingelsson, Martin
%A Dartigues, Jean-François
%A Seshadri, Sudha
%A Rossi, Giacomina
%A Morelli, Laura
%A Hiltunen, Mikko
%A Sims, Rebecca
%A van der Flier, Wiesje
%A Andreassen, Ole A
%A Arboleda, Humberto
%A Cruchaga, Carlos
%A Escott-Price, Valentina
%A Ruiz, Agustín
%A Lee, Kun Ho
%A Ikeuchi, Takeshi
%A Ramirez, Alfredo
%A Gim, Jungsoo
%A Logue, Mark
%A Lambert, Jean-Charles
%T Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
%J Nature genetics
%V 57
%N 7
%@ 1061-4036
%C London
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2025-00890
%P 1598 - 1610
%D 2025
%X A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
%K Alzheimer Disease: genetics
%K Alzheimer Disease: epidemiology
%K Alzheimer Disease: cerebrospinal fluid
%K Humans
%K Multifactorial Inheritance: genetics
%K Genetic Predisposition to Disease
%K White People: genetics
%K Genome-Wide Association Study
%K Europe: epidemiology
%K Apolipoproteins E: genetics
%K Female
%K Risk Factors
%K Male
%K Polymorphism, Single Nucleotide
%K Aged
%K Biomarkers: cerebrospinal fluid
%K Genetic Risk Score
%K Apolipoproteins E (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40533518
%2 pmc:PMC12283339
%R 10.1038/s41588-025-02227-w
%U https://pub.dzne.de/record/280053