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000280053 0247_ $$2pmid$$apmid:40533518
000280053 0247_ $$2pmc$$apmc:PMC12283339
000280053 0247_ $$2ISSN$$a1061-4036
000280053 0247_ $$2ISSN$$a1546-1718
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000280053 037__ $$aDZNE-2025-00890
000280053 041__ $$aEnglish
000280053 082__ $$a570
000280053 1001_ $$00009-0005-2606-2765$$aNicolas, Aude$$b0
000280053 245__ $$aTransferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
000280053 260__ $$aLondon$$bMacmillan Publishers Limited, part of Springer Nature$$c2025
000280053 3367_ $$2DRIVER$$aarticle
000280053 3367_ $$2DataCite$$aOutput Types/Journal article
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000280053 3367_ $$2BibTeX$$aARTICLE
000280053 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000280053 3367_ $$00$$2EndNote$$aJournal Article
000280053 520__ $$aA polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
000280053 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000280053 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000280053 650_7 $$2NLM Chemicals$$aApolipoproteins E
000280053 650_7 $$2NLM Chemicals$$aBiomarkers
000280053 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000280053 650_2 $$2MeSH$$aAlzheimer Disease: epidemiology
000280053 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000280053 650_2 $$2MeSH$$aHumans
000280053 650_2 $$2MeSH$$aMultifactorial Inheritance: genetics
000280053 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000280053 650_2 $$2MeSH$$aWhite People: genetics
000280053 650_2 $$2MeSH$$aGenome-Wide Association Study
000280053 650_2 $$2MeSH$$aEurope: epidemiology
000280053 650_2 $$2MeSH$$aApolipoproteins E: genetics
000280053 650_2 $$2MeSH$$aFemale
000280053 650_2 $$2MeSH$$aRisk Factors
000280053 650_2 $$2MeSH$$aMale
000280053 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000280053 650_2 $$2MeSH$$aAged
000280053 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000280053 650_2 $$2MeSH$$aGenetic Risk Score
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