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@ARTICLE{Nicolas:280053,
author = {Nicolas, Aude and Sherva, Richard and Grenier-Boley,
Benjamin and Kim, Yoontae and Kikuchi, Masataka and Timsina,
Jigyasha and de Rojas, Itziar and Dalmasso, María Carolina
and Zhou, Xiaopu and Le Guen, Yann and Arboleda-Bustos,
Carlos E and Camargos Bicalho, Maria Aparecida and Guerchet,
Maëlenn and van der Lee, Sven and Goss, Monica and
Castillo, Atahualpa and Bellenguez, Céline and Küçükali,
Fahri and Satizabal, Claudia L and Fongang, Bernard and
Yang, Qiong and Peters, Oliver and Schneider, Anja and
Dichgans, Martin and Rujescu, Dan and Scherbaum, Norbert and
Deckert, Jürgen and Riedel-Heller, Steffi and Hausner,
Lucrezia and Molina-Porcel, Laura and Düzel, Emrah and
Grimmer, Timo and Wiltfang, Jens and Heilmann-Heimbach,
Stefanie and Moebus, Susanne and Tegos, Thomas and Scarmeas,
Nikolaos and Dols-Icardo, Oriol and Moreno, Fermin and
Pérez-Tur, Jordi and Bullido, María J and Pastor, Pau and
Sánchez-Valle, Raquel and Álvarez, Victoria and Cao, Han
and Ip, Nancy Y and Fu, Amy K Y and Ip, Fanny C F and
Olivar, Natividad and Muchnik, Carolina and Cuesta, Carolina
and Campanelli, Lorenzo and Solis, Patricia and Politis,
Daniel Gustavo and Kochen, Silvia and Brusco, Luis Ignacio
and Boada, Mercè and García-González, Pablo and Puerta,
Raquel and Mir, Pablo and Real, Luis M and Piñol-Ripoll,
Gerard and García-Alberca, Jose María and Royo, Jose Luís
and Rodriguez-Rodriguez, Eloy and Soininen, Hilkka and
Heikkinen, Sami and de Mendonça, Alexandre and Mehrabian,
Shima and Traykov, Latchezar and Hort, Jakub and Vyhnalek,
Martin and Rasmussen, Katrine Laura and Thomassen, Jesper
Qvist and Pijnenburg, Yolande A L and Holstege, Henne and
van Swieten, John C and Seelaar, Harro and Claassen, Jurgen
A H R and Jansen, Willemijn J and Ramakers, Inez and Verhey,
Frans and van der Lugt, Aad and Scheltens, Philip and
Ortega-Rojas, Jenny and Concha Mera, Ana Gabriela and
Mahecha, Maria F and Pardo, Rodrigo and Arboleda, Gonzalo
and Bahrami, Shahram and Fominykh, Vera and Selbæk, Geir
and Graff, Caroline and Papenberg, Goran and Giedraitis,
Vilmantas and Boland, Anne and Deleuze, Jean-François and
de Marco, Luiz Armando and de Moraes, Edgar Nunes and de
Mattos Viana, Bernardo and Túlio Gualberto Cintra, Marco
and Juarez-Cedillo, Teresa and Griswold, Anthony J and
Forund, Tatiana and Haines, Jonathan and Farrer, Lindsay and
DeStefano, Anita and Wijsman, Ellen and Mayeux, Richard and
Pericak-Vance, Margaret and Kunkle, Brian and Goate, Alison
and Schellenberg, Gerard D and Vardarajan, Badri and Wang,
Li-San and Leung, Yuk Yee and Dalgard, Clifton L and
Nicolas, Gael and Wallon, David and Dufouil, Carole and
Pasquier, Florence and Hanon, Olivier and Debette,
Stéphanie and Grünblatt, Edna and Popp, Julius and Angel,
Bárbara and Gloger, Sergio and Chacon, Maria Victoria and
Aranguiz, Rafael and Orellana, Paulina and Slachevsky,
Andrea and Gonzalez-Billault, Christian and Albala, Cecilia
and Fuentes, Patricio and Sachdev, Perminder and Mather,
Karen A and Hauger, Richard L and Merritt, Victoria and
Panizzon, Matthew and Zhang, Rui and Gaziano, J Michael and
Ghidoni, Roberta and Galimberti, Daniela and Arosio,
Beatrice and Mecocci, Patrizia and Solfrizzi, Vincenzo and
Parnetti, Lucilla and Squassina, Alessio and Tremolizzo,
Lucio and Borroni, Barbara and Nacmias, Benedetta and
Caffarra, Paolo and Seripa, Davide and Rainero, Innocenzo
and Daniele, Antonio and Piras, Fabrizio and Leonard,
Hampton L and Yokoyama, Jenifer S and Nalls, Mike A and
Miyashita, Akinori and Hara, Norikazu and Ozaki, Kouichi and
Niida, Shumpei and Williams, Julie and Masullo, Carlo and
Amouyel, Philippe and Preux, Pierre-Marie and Mbelesso,
Pascal and Bandzouzi, Bébène and Saykin, Andy and Jessen,
Frank and Kehoe, Patrick G and Van Duijn, Cornelia and Ben
Salem, Nesrine and Frikke-Schmidt, Ruth and Cherni, Lotfi
and Greicius, Michael D and Tsolaki, Magda and
Sánchez-Juan, Pascual and Romano Silva, Marco Aurélio and
Porter, Tenielle and Laws, Simon M and Sleegers, Kristel and
Ingelsson, Martin and Dartigues, Jean-François and
Seshadri, Sudha and Rossi, Giacomina and Morelli, Laura and
Hiltunen, Mikko and Sims, Rebecca and van der Flier, Wiesje
and Andreassen, Ole A and Arboleda, Humberto and Cruchaga,
Carlos and Escott-Price, Valentina and Ruiz, Agustín and
Lee, Kun Ho and Ikeuchi, Takeshi and Ramirez, Alfredo and
Gim, Jungsoo and Logue, Mark and Lambert, Jean-Charles},
collaboration = {EADB},
othercontributors = {Moreno-Grau, Sonia and Amin, Najaf and Holmans, Peter A and
Kleineidam, Luca and Aarsland, Dag and Garcia-Gonzalez,
Pablo and Abdelnour, Carla and Alarcón-Martín, Emilio and
Alcolea, Daniel and Alegret, Montserrat and Alvarez, Ignacio
and Armstrong, Nicola J and Anthoula, Tsolaki and
Appollonio, Ildebrando and Arcaro, Marina and Archetti,
Silvana and Arias Pastor, Alfonso and Athanasiu, Lavinia and
Bailly, Henri and Banaj, Nerisa and Baquero, Miquel and
Pastor, Ana Belén and Bellini, Sonia and Berr, Claudine and
Besse, Céline and Bessi, Valentina and Binetti, Giuliano
and Bizarro, Alessandra and Blesa, Rafael and Boschi, Silvia
and Bossù, Paola and Bråthen, Geir and Bresner, Catherine
and Brodaty, Henry and Brookes, Keeley J and Buiza-Rueda,
Dolores and Bürger, Katharina and Burholt, Vanessa and
Calero, Miguel and Chene, Geneviève and Carracedo, Ángel
and Cecchetti, Roberta and Cervera-Carles, Laura and
Charbonnier, Camille and Chillotti, Caterina and Ciccone,
Simona and Clarimon, Jordi and Clark, Christopher and Conti,
Elisa and Corma-Gómez, Anaïs and Giuffrè, Guido Maria and
Custodero, Carlo and Daian, Delphine and Dardiotis,
Efthimios and de Deyn, Peter Paul and Del Ser, Teodoro and
Denning, Nicola and Diehl-Schmid, Janine and Diez-Fairen,
Mónica and Rossi, Paolo Dionigi and Djurovic, Srdjan and
Duron, Emmanuelle and Engelborghs, Sebastiaan and Espinosa,
Ana and Ewers, Michael and Fabrizio, Tagliavini and Nielsen,
Sune Fallgaard and Farotti, Lucia and Fenoglio, Chiara and
Fernández-Fuertes, Marta and Ferreira, Catarina B and
Ferri, Evelyn and Fin, Bertrand and Fischer, Peter and
Fladby, Tormod and Fließbach, Klaus and Fortea, Juan and
Foroud, Tatiana M and Fostinelli, Silvia and Fox, Nick C and
Franco-Macías, Emlio and Frank-García, Ana and Froelich,
Lutz and García-Alberca, Jose Maria and Garcia-Madrona,
Sebastian and Garcia-Ribas, Guillermo and Giegling, Ina and
Giorgio, Giaccone and Goldhardt, Oliver and
González-Pérez, Antonio and Grande, Giulia and Green, Emma
and Guetta-Baranes, Tamar and Haapasalo, Annakaisa and
Hadjigeorgiou, Georgios and Hampel, Harald and Hardy, John
and Hartmann, Annette M and Harwood, Janet and Helisalmi,
Seppo and Heneka, Michael T and Hernández, Isabel and
Herrmann, Martin J and Hoffmann, Per and Holmes, Clive and
Huerto Vilas, Raquel and Hulsman, Marc and Biessels, Geert
Jan and Johansson, Charlotte and Kilander, Lena and
Ståhlbom, Anne Kinhult and Kivipelto, Miia and Koivisto,
Anne and Kornhuber, Johannes and Kosmidis, Mary H and Lage,
Carmen and Laukka, Erika J and Lauria, Alessandra and
Lehtisalo, Jenni and Lerch, Ondrej and Lleó, Alberto and
López-de Munain, Adolfo and Love, Seth and Löwemark, Malin
and Luckcuck, Lauren and Macías, Juan and MacLeod,
Catherine A and Maier, Wolfgang and Mangialasche, Francesca
and Spallazzi, Marco and Marquié, Marta and Marshall,
Rachel and Montes, Angel Martín and Martínez Rodríguez,
Carmen and Mead, Simon and Medina, Miguel and Meggy, Alun
and Mendoza, Silvia and Menéndez-González, Manuel and Mol,
Merel and Montrreal, Laura and Morgan, Kevin and Möthen,
Markus M and Ngandu, Tiia and Nordestgaard, Børge G and
Olaso, Robert and Orellana, Adelina and Orsini, Michela and
Ortega, Gemma and Padovani, Alessandro and Pérez-Cordón,
Alba and Pericard, Pierre and Pineda, Juan A and Pisanu,
Claudia and Polak, Thomas and Posthuma, Danielle and
Priller, Josef and Quenez, Olivier and Quintela, Inés and
Rábano, Alberto and Reinders, Marcel J T and Riederer,
Peter and Roberto, Natalia and Rongve, Arvid and Allende,
Irene Rosas and Rosende-Roca, Maitée and Royo, Jose Luis
and Rubino, Elisa and Sáez, María Eugenia and Sakka,
Paraskevi and Saltvedt, Ingvild and Sanabria, Ángela and
Bernal Sánchez-Arjona, María and Sanchez-Garcia,
Florentino and Sánchez-Juan, Pascual and Sando, Sigrid B
and Scamosci, Michela and Scarpini, Elio and Scherer, Martin
and Schmid, Matthias and Schott, Jonathan M and Shadrin,
Alexey A and Skrobot, Olivia and Solomon, Alina and Sorbi,
Sandro and Sotolongo-Grau, Oscar and Spottke, Annika and
Stordal, Eystein and Tartan, Juan Pablo and Tárraga, Lluís
and Tesí, Niccolo and Thalamuthu, Anbupalam and Thomas,
Tegos and Tybjærg-Hansen, Anne and Uitterlinden, Andre and
Ullgren, Abbe and Ulstein, Ingun and Valero, Sergi and Van
Broeckhoven, Christine and Van Dongen, Jasper and
Vandenberghe, Rik and Vidal, Jean-Sébastien and Vogelgsang,
Jonathan and Wagner, Michael and Weinhold, Leonie and
Windle, Gill and Woods, Bob and Yannakoulia, Mary and
Zulaica, Miren},
title = {{T}ransferability of {E}uropean-derived {A}lzheimer's
disease polygenic risk scores across multiancestry
populations.},
journal = {Nature genetics},
volume = {57},
number = {7},
issn = {1061-4036},
address = {London},
publisher = {Macmillan Publishers Limited, part of Springer Nature},
reportid = {DZNE-2025-00890},
pages = {1598 - 1610},
year = {2025},
abstract = {A polygenic score (PGS) for Alzheimer's disease (AD) was
derived recently from data on genome-wide significant loci
in European ancestry populations. We applied this PGS to
populations in 17 European countries and observed a
consistent association with the AD risk, age at onset and
cerebrospinal fluid levels of AD biomarkers, independently
of apolipoprotein E locus (APOE). This PGS was also
associated with the AD risk in many other populations of
diverse ancestries. A cross-ancestry polygenic risk score
improved the association with the AD risk in most of the
multiancestry populations tested when the APOE region was
included. Finally, we found that the PGS/polygenic risk
score captured AD-specific information because the
association weakened as the diagnosis was broadened. In
conclusion, a simple PGS captures the AD-specific genetic
information that is common to populations of different
ancestries, although studies of more diverse populations are
still needed to better characterize the genetics of AD.},
subtyp = {Letter},
keywords = {Alzheimer Disease: genetics / Alzheimer Disease:
epidemiology / Alzheimer Disease: cerebrospinal fluid /
Humans / Multifactorial Inheritance: genetics / Genetic
Predisposition to Disease / White People: genetics /
Genome-Wide Association Study / Europe: epidemiology /
Apolipoproteins E: genetics / Female / Risk Factors / Male /
Polymorphism, Single Nucleotide / Aged / Biomarkers:
cerebrospinal fluid / Genetic Risk Score / Apolipoproteins E
(NLM Chemicals) / Biomarkers (NLM Chemicals)},
cin = {AG Peters / AG Schneider / AG Dichgans / AG Düzel / AG
Wiltfang / AG Jessen / Patient Studies (Bonn)},
ddc = {570},
cid = {I:(DE-2719)5000000 / I:(DE-2719)1011305 /
I:(DE-2719)5000022 / I:(DE-2719)5000006 / I:(DE-2719)1410006
/ I:(DE-2719)1011102 / I:(DE-2719)1011101},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40533518},
pmc = {pmc:PMC12283339},
doi = {10.1038/s41588-025-02227-w},
url = {https://pub.dzne.de/record/280053},
}
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